This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The project aims to evaluate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence and proliferative potential. The research will investigate factors such as...
The National Institutes of Health (NIH) Office of the Director awarded a $1,404,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Regents of the University of Michigan. The grant, titled "Turning Back Biological Clock: Mechanisms of Age Reversal in a Whole Organism," aims to investigate the molecular and cellular mechanisms underlying age reversal in the planarian S. mediterranea. Specifically, the research will examine two potential mechanisms for...
The National Institute on Aging (NIA) awarded a $1,639,148 Project Grant (CFDA 93.866 - Aging Research) to the University of Rochester. The project aims to fully characterize a subset of senescent cells (termed "detrimental senescent cells" or DSCs) within bone fracture calluses and investigate how these DSCs impair fracture healing in aged mice. The research will explore the mechanisms by which DSCs, through secretion of factors like TGF-β1 and TIMP2, negatively regulate the expansion...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $793,777 to the J. David Gladstone Institutes to conduct research on the impact of mitochondrial genome architecture on the accumulation of somatic mitochondrial DNA (mtDNA) mutations and their role in cellular aging and age-related degenerative diseases. The study will utilize long-read sequencing approaches to quantify accessibility, mutations, and damage along individual mtDNA...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $153,512.00 to the Regents of the University of Minnesota to conduct research on the relationship between lipid metabolism, mitochondrial stress, and cellular senescence. The key objectives are to: 1) use proteomics to characterize mitochondrial protein targets of carbonylation during obesity and aging, and 2) investigate the role of mitochondrial stress and signaling on adipose tissue...
This $2,010,291 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to The Johns Hopkins University. The grant aims to leverage whole-genome sequencing, metabolomics, and proteomics data to identify novel biomarkers and causal relationships between mitochondrial function and aging-related diseases, including all-cause mortality, cardiovascular disease, and frailty. The research will first identify plasma metabolites...
This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
This $312,900 Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports research to identify the genetic basis of extraordinary lifespan in a model organism, the nematode Caenorhabditis elegans. The 5-year project aims to: (1) discover the genetic variants responsible for longevity in a naturally occurring long-lived C. elegans isolate, (2) analyze how natural variation affects lifespan and develop tissue-specific "aging...
The National Institute on Aging (NIA) awarded a $422,419 Project Grant (CFDA 93.866 - Aging Research) to the University of California, Los Angeles (UCLA) to conduct research aimed at understanding the cellular mechanisms underlying tissue and cellular rejuvenation. The project will map the transcriptomic, chromatin, and epigenetic changes that occur during partial cellular reprogramming with the OSKM transcription factors, with the goal of identifying key regulators and pathways that can be...
This $430,101 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University Medical Center (VUMC) will fund research to identify new genes and genetic variants responsible for telomere shortening, telomere disease risk, and premature aging. The project aims to determine the genetic basis of telomere shortening across diverse tissues, explore the phenome-wide consequences of telomere length using large-scale biobank data, and identify...