Project Grant P30AG092746

Award Date 7/1/25
Completion Date 5/31/30
Dollars Obligated $924K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
New York, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,270,502 to the Regents of the University of Minnesota to establish the Minnesota Nathan Shock Center of Excellence on Genome Integrity and Aging. The center will provide access to cores that can accurately measure DNA damage, DNA repair activity, and epigenetic changes associated with aging. It will also provide access to mouse and human cells and tissues, as well as mouse models with reduced...
This federal Project Grant award, identified as P30AG092586, was provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program. The award, totaling $1,271,506, will support the Wisconsin Nathan Shock Center (WINSC) to conduct research at the intersection of aging, metabolism, and translation. The key objectives of the WINSC are to: 1) promote, coordinate, and enhance research in the basic biology of aging with a focus on aging, metabolism, and translation;...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support research by Tufts University School of Medicine to develop metabolomics clocks as a tool to explore the mechanisms of aging. The total funding amount is $592,507 and the award period runs from Sep 30, 2024 to Jun 30, 2029. The key objectives of the project are to: 1) develop sex- and tissue-specific metabolome clocks in the Drosophila model system that can...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The project aims to evaluate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence and proliferative potential. The research will investigate factors such as...
This Project Grant award, totaling $418,364.00, was issued by the National Institute on Aging (CFDA 93.866 - Aging Research) to Wake Forest University Health Sciences to conduct a comprehensive study on lifespan and biological aging across multiple nonhuman primate (NHP) species. The key objectives are: Generate the most accurate sex-specific lifespan and age-at-death distributions for 11 biomedically-relevant NHP species, and test the influence of factors like body size, age at reproductive...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $3,070,537 Project Grant to the University of Maryland, College Park to develop and validate a new proteomics platform called Scalable Single-Cell Mass Spectrometry (SCEMAS). This platform aims to enable high-sensitivity mass spectrometry approaches necessary to characterize proteomic changes associated with aging, such as in neurons, neuronal subtypes, and neuronal subcompartments,...
This $312,900 Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports research to identify the genetic basis of extraordinary lifespan in a model organism, the nematode Caenorhabditis elegans. The 5-year project aims to: (1) discover the genetic variants responsible for longevity in a naturally occurring long-lived C. elegans isolate, (2) analyze how natural variation affects lifespan and develop tissue-specific "aging...
The Research Foundation of the City University of New York (RFCUNY), acting as the fiscal administrator for the City University of New York (CUNY), has received a $458,510 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866). This award will support the development of a transformative deep learning framework to integrate multi-omics data and elucidate the molecular mechanisms underlying exceptional longevity (EL). The key objectives are to: 1)...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $687,288 will fund a comparative analysis of somatic mutational processes across primate species with diverse lifespans. The primary awardee, the University of California, Berkeley, will collaborate with researchers at the University of Cambridge and Wellcome Sanger Institute to: Generate a comprehensive atlas of somatic mutation rates, signatures, and clonal dynamics across 10 tissue...
Duke University received a $1,019,484.58 Project Grant award from the National Institutes of Health's National Institute on Aging under the Aging Research program (CFDA 93.866) for the period September 1, 2021 through May 31, 2022. The award will support research using the nematode C. elegans as a model organism to study aging-associated neurodegeneration at the molecular level, with the goals of uncovering novel mechanisms underlying this process and establishing C. elegans neurons as a...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will establish the Upstate NY Nathan Shock Center of Excellence in Basic Biology of Aging (Upstate NSC) to advance comparative biology research on aging. The $924,002 award, with a period of performance from July 1, 2025 to May 31, 2030, will fund four research resource cores:

  1. The Live Animal Core will maintain and share unique animal models of aging, including naked mole rats, Damaraland mole rats, African spiny mice, and horses.
  2. The Unconventional Invertebrate Core will focus on eusocial ants and wasps with dramatic lifespan variations within the same species.
  3. The Frozen Zoo Core will maintain tissue collections from over 50 mammalian species.
  4. The Comparative Omics Core will process samples and develop novel aging research technologies.

The Upstate NSC will work closely with the aging research community to attract new talent, distribute resources, and provide leadership in advancing the field of comparative biology of aging.

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