Project Grant NNX14AD01G

This federal Project Grant award, provided by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), will fund a longitudinal study on the mechanisms of radiation-induced neurocognitive decline in patients with glioma. The $667,485 award to the University of California, San Diego (UCSD) aims to: Characterize neurocognitive heterogeneity and identify cognitive phenotypes in glioma patients before and after radiation therapy (RT). Analyze...

This $440,640 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to investigate the use of oscillating electromagnetic fields to modulate glymphatic activity and brain waste clearance. The primary goal is to explore whether slow-wave entrainment induced by electromagnetic fields can enhance cerebrospinal fluid (CSF) circulation...

This $1,474,236 Project Grant award from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) supports research to characterize synaptic density changes in the brain following radiation therapy using a novel PET tracer. The project aims to use quantitative whole-brain PET imaging to evaluate the time course of synaptic density changes in irradiated rodents and correlate these changes with cognitive outcomes. A key focus is to compare synaptic density...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $474,337 to the University of Colorado-Denver for research focused on pediatric treatment-induced gliomas, also known as radiation-induced gliomas (RIGs). The research aims to discover and validate germline risk factors for RIGs, identify key pathways for tumor growth and...

The University of California, San Diego will receive $400,000 from the National Science Foundation under the Engineering (CFDA 47.041) federal grant program to research the mechanisms of microgravity accelerated aging on human brain organoids from October 1, 2021 to September 30, 2024. Through this three-year Project Grant, UCSD researchers will study how microgravity exposure impacts the aging process in miniaturized human brain tissues grown in a laboratory, with the goal of furthering...

This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $659,568 to The University of Kentucky Research Foundation to conduct a Phase I clinical trial of autologous peripheral nerve tissue implants into the nucleus basalis of Meynert in patients with Parkinson's disease and cognitive impairment. The goal is to assess the feasibility and safety of this approach to potentially maintain cholinergic neuron function and circuits, which are impaired in...

This $500,000 project grant from the National Science Foundation Division of Electrical, Communications and Cyber Systems Engineering program will fund research into magnetoelectric nanoparticles as multi-field controlled devices for wireless brain stimulation. Led by researchers at the University of Miami, the three-year project aims to experimentally study the feasibility of using magnetoelectric nanoparticles to achieve wireless deep brain stimulation with sub-millimeter spatial resolution...

This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,193,500.00 to the Lovelace Biomedical Research Institute to conduct research on the mechanisms underlying the effects of transcranial alternating current stimulation (tACS) and transcranial direct current stimulation (tDCS) on cerebral microcirculation and neuronal activity. The research aims to dissect and differentiate the vascular and neural mechanisms of these non-invasive brain...

This $499,943 federal Project Grant award from the Department of Energy (DOE) Office of Science Financial Assistance Program (CFDA 81.049) supports a project titled "HUMAN BONE-MARROW MODEL FOR RESPONSE NETWORK STUDIES OF LOW DOSE / LOW DOSE-RATE RADIATION EXPOSURES" to be conducted by The Trustees of Columbia University in the City of New York, through its Health Sciences Division. The project aims to advance scientific understanding of human physiological responses to low-dose and...

This $221,120 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research focused on improving neural progenitor cell survival and migration to enhance neurovascular communication and promote recovery after stroke. The key objectives are to investigate the potential of adult central nervous system endothelial cells to express...