The National Institute on Aging (NIA) awarded a $1,193,500 Project Grant (CFDA 93.866 - Aging Research) to the Lovelace Biomedical Research Institute to investigate the mechanisms by which transcranial alternating current stimulation (tACS) and transcranial direct current stimulation (tDCS) modulate cerebral microcirculation and endothelial function. The research aims to dissect the effects of these transcranial electrical stimulation (TES) techniques on vascular responses and their potential influence on neuronal activity. The 2-year project will utilize in vivo multiphoton microscopy in awake mice to assess changes in microvascular tone, circulation, and blood-brain barrier permeability during and after tACS and tDCS, with the use of nitric oxide synthase modulators and genetic knockout models. This work is intended to provide a more comprehensive understanding of the physiological mechanisms underlying the cerebrovascular effects of TES, which could help inform optimal stimulation parameters and protocols for medical and performance applications.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 1/9/25 | ||
| Not listed | $596.8k | 9/10/24 | ||
| Not listed | $596.8k | 9/10/24 |