This federal Project Grant award of $606,548 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support the development of a new "mesoscopic electrophysiology" recording system at the University of Pittsburgh. The goal is to create a 3-dimensional grid of 1,920 intracranial electrode contacts across an entire brain hemisphere to enable full-brain,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $640,000 to Northeastern University to develop and apply new intravital microscopy techniques. The goal is to gain greater insight into the effects of gamma entrainment, a promising non-pharmacological neuromodulation technique for Alzheimer's disease (AD) and other brain pathologies. The project will focus on characterizing how gamma entrainment influences cerebral energy metabolism and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $753,794.60 to the Research Foundation For Mental Hygiene, Inc. (RFMH) at its Nathan S Kline Institute Division to elucidate the role of the supramammillary nucleus (SUM) as a key modulator of hippocampal theta oscillations and explore its potential as a therapeutic target for age-related memory deficits. The funded project aims to: 1) dissect the SUM-hippocampal circuits and their physiological...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $367,261 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program to the Regents of the University of Minnesota. This 2-year project aims to develop an experimentally-validated numerical simulation that couples a physiologically-realistic spreading depolarization (SD) model to a detailed glymphatic system model. The simulation...
This Project Grant award of $408,400 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund the development and assessment of a wearable magnetoencephalography (MEG) system for use in children. The funding will support two key objectives: Developing and optimizing an optically pumped magnetometers (OPM)-based MEG recording system that can accommodate the variable...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $701,011.00 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the underlying mechanisms of low-intensity focused ultrasound (LIFU) neuromodulation. The project aims to systematically map the parameter space of LIFU's impact on...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,498,158 to Synaptic Health LLC to develop a novel closed-loop feedback neuromodulation system to improve slow wave sleep in Alzheimer's disease patients. The goal of this Phase I project is to create a testable prototype that can sense sleep architecture and provide peripheral neuromodulation stimulation to individuals over 65, a high-risk group for Alzheimer's disease. Successful...
This Project Grant award of $2,156,000.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports a research project to develop and validate non-invasive neuroimaging methods for quantifying brain oxygen availability, pH, and carbon dioxide levels. The goal is to better understand the relationship between cerebral blood flow, neuronal metabolic demands, and the regulation of waste products, in order to identify the underlying causes of brain...
This Project Grant award from the National Institute on Aging (CFDA 93.866, Aging Research) will provide $426,829 to Virginia Polytechnic Institute & State University from September 1, 2024 to May 31, 2026 to develop a microphysiological system that models the brain-meninges-lymph node axis in both healthy conditions and Alzheimer's disease. The goal is to create a modular, all-human system that can be used to study the interactions between the brain, meninges, and lymph nodes, and the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $2,317,887 will be used by Indiana University Indianapolis to map paravascular cerebrospinal fluid (PCSF) signatures associated with healthy aging, aging with hypertension, and Alzheimer's disease (AD). The researchers will leverage dynamic diffusion-weighted imaging, a novel neuroimaging technique, to quantify PCSF dynamics and volume near major arteries - a key component of the glymphatic...