Project Grant NNX13AB66G

This $2.3 million project grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund research on hippocampal-cortical contributions to spatial learning and memory in freely behaving macaques. Over a three-year period from May 2022 to April 2025, researchers at Vanderbilt University will use high-density wireless recordings to test predictions from complementary learning systems theory regarding the roles of hippocampal subregions and...

This Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) aims to investigate the role of the dentate gyrus region of the hippocampus in the pathophysiology of psychosis. The $246,000 grant awarded to The University of Texas Southwestern Medical Center will use chemogenetic techniques to gradually inhibit dentate gyrus activity in the hippocampus of mice, while longitudinally monitoring hippocampal neural activity. The overarching...

The National Institute of Mental Health (NIMH) awarded a $232,183 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of Texas at Austin to investigate the functional differentiation of dorsal and ventral hippocampal place cell populations in rats. The research aims to determine whether coordinated place cell sequences in the dorsal and ventral hippocampus encode and consolidate spatial versus non-spatial (emotional/motivational) components of memories. The project...

This three-year, $3,027,312 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research into the role of hippocampal inhibitory interneurons in novel memory formation and how this process is disrupted in Alzheimer's disease. Specifically, the awardee, Georgia Tech Research Corporation, will record electrical activity from inhibitory and excitatory neurons in mice and selectively stimulate parvalbumin-positive interneurons to test...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) funds research to investigate the inhibitory connections between the hippocampus and the supramammillary area (SUM) of the brain. The $565,552 award to the Regents of the University of Minnesota will be used to examine the nature and function of this hippocampal-SUM connectivity, with the...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), is valued at $402,813 and will support research investigating the reciprocal interactions between neural circuit architecture and synaptic function in the hippocampus. The 5-year project, running from September 2024 to August 2029, will utilize large-scale in vivo...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research investigating the mechanisms by which neonatal hypoxia impairs hippocampal development and learning/memory functions in a preterm-equivalent mouse model. The $472,616 award, valid from August 15, 2024 to July 31, 2029, will enable researchers at Oregon...

This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $481,250 to Vanderbilt University Medical Center (VUMC) to conduct research on mapping relational memory deficits and their hippocampal correlates in schizophrenia. The research aims to establish a cognitive marker sensitive to hippocampal structure that can track clinical and neural progression in schizophrenia. The project will use a novel...

The National Institute of Mental Health (NIMH) awarded a $625,108 Project Grant (CFDA 93.242 - Mental Health Research Grants) to the University of California, Irvine to conduct research on the role of the lateral entorhinal cortex (LEC) in associative memory formation. The project aims to identify the circuit mechanisms by which the LEC integrates multiple sensory inputs to enable declarative memory encoding and retrieval. The research involves multi-faceted analytical methods including in...

This $415,958 Project Grant award, funded by the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074), supports research by Florida Atlantic University (FAU) to explore the role of a specific type of inhibitory neurons, called cholecystokinin-expressing (CCK) neurons, in the hippocampal circuit and their contribution to memory discrimination and pattern separation. The key objectives of the research project are to determine how the remodeling of the CCK neuron network...