Project Grant R01NS139469
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $565,257 to The Research Foundation For The State University Of New York (RF-SUNY) at the University at Albany on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This one-year project grant, which concludes July 31, 2026, supports basic neuroscience research investigating presynaptic modulation of synaptic...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Regents of the University of California, San Francisco $800,384 under the Mental Health Research Grants program (CFDA 93.242) on March 10, 2026, for a project titled "Molecular and Functional Dissection of Prefrontal-Hippocampal Long-Range Inhibition." This Project Grant supports basic neuroscience research investigating the mechanisms through which the prefrontal cortex exerts top-down control...
- Federal Project Grant Summary Emory University received a $430,375 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded March 15, 2026, with a completion date of March 14, 2028. The project, "Precision Targeting of Hippocampal Subfields with AAVs," will develop cell type-specific adeno-associated virus (AAV) vectors utilizing enhancer-driven regulatory sequences to enable selective genetic access to...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $489,197 Project Grant to the Research Foundation For Mental Hygiene, Inc. (RFMH), New York State Psychiatric Institute, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). Awarded on July 1, 2025, with a project completion date of June 30, 2030, this five-year research initiative will investigate the neural circuits underlying cue...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded UC San Diego a Project Grant totaling $109,076 under the Mental Health Research Grants program (CFDA 93.242) to support basic neuroscience research investigating the neural mechanisms underlying hunger-induced suppression of social and affective behaviors. The research, initiated December 30, 2025 and concluding June 29, 2029, will identify specific neural circuits and downstream brain regions through which...
- This five-year, $548,445 project grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) will fund research at Louisiana State University to investigate the functional significance of glutamate projections from the ventral tegmental area to the hippocampus and their role in novelty learning and context discrimination. Using optogenetic modulation and neural recording techniques in freely behaving mice, the research aims to determine how these neural circuits...
- This federal Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) provides $446,627 to the University of California, San Diego to conduct research on the function of the subiculum region of the brain and its role in spatial cognition and navigation. The research aims to systematically investigate orientation tuning and encoding of directional information in the subiculum, with a focus on how this brain region supports flexible navigation...
- This project grant, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports fundamental neuroscience research investigating cell type-specific mechanisms of glutamatergic synapse function and organization. Awarded to Tufts University School of Medicine on October 17, 2025, with $136,050 obligated through October 23, 2027, the research focuses on understanding how impaired inhibitory signaling contributes to...
- This $339,664 National Science Foundation project grant supports research into the neural mechanisms of generalization in the ventral hippocampus at the University of Iowa. The goal is to determine how distinct cell types in the ventral hippocampus modulate selective versus generalized emotional responses. Investigators will combine in vivo single-unit recording, local field potential recording, chemogenetic silencing/activation, optogenetic circuit analysis, and in vitro patch clamping...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a Project Grant of $778,548 to the Research Foundation For Mental Hygiene, Inc. (Nathan S Kline Institute for Psychiatric Research) on September 19, 2025, under the Mental Health Research Grants program (CFDA 93.242). This five-year research initiative, concluding July 31, 2030, investigates the neural mechanisms underlying social cognitive deficits in schizophrenia, with particular focus on the third visual...
INHIBITORY HIPPOCAMPAL PROJECTIONS TO THE SUPRAMAMMILLARY AREA - PROJECT SUMMARY THE SUPRAMAMMILLARY AREA (SUM) IS INCREASINGLY APPRECIATED FOR ITS ROLE IN A VARIETY OF FUNCTIONS, INCLUDING SPATIAL AND SOCIAL NOVELTY PROCESSING VIA ITS CONNECTIONS WITH THE HIPPOCAMPUS. SPECIFICALLY, THE SUM HAS PROJECTIONS TO THE CA2 AND VENTRAL DENTATE GYRUS (DG), BELIEVED TO BE IMPORTANT FOR SOCIAL PROCESSING, AND TO THE DORSAL DG, BELIEVED TO BE IMPORTANT FOR SPATIAL AND CONTEXTUAL PROCESSING. THE HIPPOCAMPUS PROVIDES DIRECT INHIBITORY INPUT TO THE SUM, BUT THE NATURE AND FUNCTION OF THIS CONNECTIVITY IS COMPLETELY UNKNOWN. THE STUDIES OUTLINED IN THE PROPOSAL WOULD PROVIDE IMPORTANT BASIC SCIENCE GROUNDWORK FOR UNDERSTANDING THIS CONNECTIVITY, WITH ULTIMATE POTENTIAL IMPACTS FOR BETTER UNDERSTANDING AND TREATING A RANGE OF NEUROLOGICAL DISORDERS, INCLUDING BUT NOT LIMITED TO TEMPORAL LOBE EPILEPSY. THIS INCLUDES EXAMINING THE HIPPOCAMPAL NEURONS PROVIDING THE INHIBITORY INPUT TO THE SUM, EXAMINING WHICH SUBPOPULATIONS OF SUM NEURONS RECEIVE INHIBITORY HIPPOCAMPAL INPUT, AND THE IN VIVO IMPACT OF MANIPULATION OF INHIBITORY HIPPOCAMPAL INPUTS TO THE SUM. BASED ON OUR PRELIMINARY DATA, WE PREDICT THAT THERE ARE AT LEAST TWO POPULATIONS OF HIPPOCAMPAL INHIBITORY NEURONS PROJECTING TO THE SUM -- ONE EXPRESSING NEURONAL NITRIC OXIDE SYNTHASE (NNOS) AND THE OTHER EXPRESSING SOMATOSTATIN - LOCATED IN EACH REGION AND ALONG THE ENTIRE ANTERIOR-POSTERIOR AXIS OF THE HIPPOCAMPUS. WE FURTHER PREDICT THE GREATEST NUMBER IN THE CA3 REGION. WE PREDICT, AND OUR PRELIMINARY DATA SUPPORTS, THAT BOTH SUM CELLS PROJECTING TO THE VENTRAL DG AND SUM CELLS PROJECTING TO THE DORSAL DG RECEIVE INHIBITORY HIPPOCAMPAL INPUTS. IMPORTANTLY, WE SEE THE STRONGEST CONNECTIVITY SO FAR FROM THE VENTRAL HIPPOCAMPUS TO SUM NEURONS PROJECTING TO THE DORSAL DG, ARGUING AGAINST A SIMPLE FEEDBACK INHIBITORY ROLE OF THIS CONNECTION. TO EXAMINE THE FUNCTION OF INHIBITORY HIPPOCAMPAL INPUTS TO THE SUM IN VIVO, WE WILL USE FIBERPHOTOMETRY TO RECORD FROM PROJECTION-DEFINED SUM POPULATIONS, DURING AN ASSORTMENT OF BEHAVIORAL TESTS, WHILE PROVIDING CLOSED-LOOP OPTOGENETIC MANIPULATION OF INHIBITORY HIPPOCAMPAL INPUTS SPECIFICALLY AT THE TIME OF OBJECT OR CONSPECIFIC INVESTIGATIONS. COLLECTIVELY, THE DATA WILL PROVIDE IMPORTANT INSIGHTS INTO THE NATURE OF HIPPOCAMPAL INHIBITORY INPUTS TO THE SUM, INCLUDING THE DEGREE TO WHICH SPECIFIC SUM POPULATIONS ARE TARGETED, AND THE FUNCTIONAL SIGNIFICANCE OF THIS CONNECTIVITY, INCLUDING AS RELATES TO SOCIAL AND SPATIAL PROCESSING.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $577.7k | 6/27/25 | ||
| Not listed | $565.6k | 6/28/24 |