Project Grant MCB9983116001

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to better understand the molecular mechanisms of HIV spread through cell-cell contact. The $515,282 award to Case Western Reserve University aims to use a novel flow cytometry assay and APEX proximity labeling to analyze how host and viral proteins and RNAs are regulated by the formation of a virological synapse...

The National Science Foundation (NSF) awarded a $955,876 Project Grant to Northwestern University to investigate the role of prion-mediated epigenetic regulation in the budding yeast, Saccharomyces cerevisiae. The project, funded through NSF's Biological Sciences program (CFDA 47.074), aims to examine how two different yeast prions, [SWI+] and [MOT3+], interact and impact global transcription and protein homeostasis. Using advanced multi-omics techniques, the research program will identify...

This $451,910 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research by Duke University to characterize the replication process and impact of retrotransposons - highly abundant genomic elements that can rewrite host genetic information and affect physiology and disease. The research aims to: 1) determine how the alternative end-joining DNA repair pathway mediates circularization...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $494,696 to The University of Texas Health Science Center at San Antonio (UTHSCSA) to conduct research on translational control mechanisms that regulate the ability of the fungal pathogen Candida albicans to respond to host environmental stresses and undergo morphological changes associated with virulence. The research...

This Project Grant award from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $910,000 over 4 years to Weill Medical College of Cornell University to conduct research on the regulation of DNA repair mechanisms and transcription at telomeres. The research aims to improve understanding of how genetic information is protected at chromosome ends, which is critical for cell and organism health. The...

This three-year, $828,217 National Science Foundation project grant supports collaborative research on RNA processing in trypanosome mitochondria at Texas A&M Agrilife Research. Funded under the Biological Sciences program (CFDA 47.074), the award will advance understanding of gene expression regulation in the single-celled parasites that cause sleeping sickness. Specifically, the award funds three objectives investigating how mRNA editing is differentially controlled across the life cycle...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $502,861 to the University of California, San Diego (UCSD) to delineate the molecular and cellular mechanisms by which HIV-1 infection alters host transcriptional and translational programs. The key objectives are to: 1) Define the dynamics and mapping of human m6Am RNA methylome in response to HIV infection and...

This $592,495 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) will support research at Dartmouth College from February 15, 2023 to January 31, 2025. The project aims to identify the molecular pathway controlling meiotic termination in budding yeast through experiments analyzing how autophagy shapes the meiotic transcriptome and proteome at different stages of meiosis. Researchers will define...

This $536,943.46 Project Grant from the National Institutes of Health National Institute of Allergy and Infectious Diseases funds research at The Scripps Research Institute-Florida on identifying host factors that regulate HIV latency and reactivation. The grant supports three aims over a six-month period: defining the roles of proteins P32, FUBP3, and PHB2 in HIV transcription and chromatin structure; investigating protein complexes associated with P32, FUBP3, and PHB2 and their interaction...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA #93.859 Biomedical Research and Research Training, will support a research program focused on studying the functional convergence at the host-virus interface. Key objectives include: Performing structural homology searches to define patterns of gene capture in diverse viruses and identify structural homologs of antiviral proteins in diverse metazoan species. Investigating the independent...