This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $857,215 to HMH Hospitals Corporation (doing business as Hackensack University Medical Center) to conduct research on how the fungal pathogen Candida albicans adapts to different host environments, such as the oral and systemic infection niches. The research aims to decipher how the fungal acetylome, regulated by the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $249,749 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Iowa. The grant supports research to develop a new approach for analyzing the transcriptional control of virulence in the fungal pathogen Aspergillus fumigatus, a leading cause of life-threatening infections in immunocompromised patients. The research aims to express a nanobody-E3 ligase fusion protein...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $251,250 to The University of Texas MD Anderson Cancer Center to develop CAR-T cell and CAR-macrophage based cell therapies to target and recruit the host immune system to protect against systemic Candida infections. The primary objectives are to generate CAR constructs by fusing Candida-specific targeting domains with...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $812,603 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to the University of Houston System. The grant aims to develop selective calcium-dependent protein kinase 1 (CDPK1) inhibitors that can efficiently access the gastrointestinal system to treat cryptosporidiosis, a significant public health threat with limited treatment options. The research will focus on structure-activity...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $782,178 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Research Foundation for the State University of New York, doing business as Stony Brook University. The grant supports research to develop novel antifungal inhibitors targeting the sterylglucosidase enzymes SGL1 and SGLA, which are essential for the pathogenicity of the fungal pathogens Cryptococcus neoformans and...
The University of Southern California (USC) received a $623,986 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The funding supports a research project to study the genetic and molecular mechanisms that enable fungi, specifically the opportunistic pathogen Saccharomyces cerevisiae, to persist and cause infections in mammalian hosts. Key objectives include: Identifying causal...
This $134,800 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research by Dr. Shakti Singh at the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The project aims to: Study the role of Hyr1/Iff-like (CAU-HIL) proteins in the virulence of the multidrug-resistant pathogen Candida auris, which causes life-threatening bloodstream infections....
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $556,375 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the J. Craig Venter Institute, Inc. (JCVI) on July 23, 2025. The grant, titled "Identifying the Molecular Determinants of Thermoadaptation and Parasitic Growth of Histoplasma capsulatum", aims to sequence and assemble approximately 150 new clinical isolates of the fungal pathogen Histoplasma capsulatum. The goal is to identify...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on a novel link between calcineurin, amino acid permease, and protein kinase A in virulence of the fungus Mucor, which causes the life-threatening condition mucormycosis. The $558,747 award to Texas Tech University Health Sciences Center aims to: 1) identify key transcription factors regulated by...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $438,038 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Regents of the University of California, Berkeley to conduct research on the regulation of infectious spore formation in the fungal pathogen Coccidioides posadasii. The project aims to use experimental and computational genomic approaches to study how Coccidioides, the causative agent of Valley Fever, preferentially...