Project Grant K99NS151036
- The National Institute of Neurological Disorders and Stroke, an institute of the National Institutes of Health, awarded The Regents of the University of California, San Francisco $205,200 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into the role of microglia in cortical interneuron development in genetic and environmental disruptions associated with autism spectrum disorder. The work...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of The University of Pennsylvania $198,164 on December 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The recipient conducted research into SCN3A-related neurodevelopmental disorder using a novel mouse model to elucidate the pathophysiology of this newly identified syndrome characterized by treatment-resistant epilepsy, intellectual...
- The National Institute of Mental Health awarded The Regents of the University of California, San Francisco (UCSF) $568,746 on August 11, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the cellular mechanisms by which autism-associated protein SYNGAP1 functions at the primary cilium. The funded research tests the hypothesis that autism spectrum disorder risk genes play pleiotropic roles across subcellular compartments, including functionally significant roles...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $430,375 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate spinal motor circuit dysfunction in autism spectrum disorder. The project examines the neural mechanisms underlying early motor impairments in ASD using two complementary mouse models: prenatal valproic acid exposure (representing environmental and...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, Los Angeles $625,859 on January 27, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate objective, quantitative measures of infant motor function as predictive biomarkers for autism spectrum disorder. The project uses wearable sensor technology and advanced computational techniques to measure motor development...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, San Diego $121,554 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Program Grant K99NS150832). The award funds research investigating pericyte regulation of central nervous system metabolism and function. The project tests hypotheses that pericytes regulate the CNS metabolome and thereby influence neurovascular...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $128,206 on September 1, 2026, under Mental Health Research Grants (CFDA 93.242, Assistance Type: Project Grant) to develop and apply next-generation imaging and perturbation technologies for mapping and manipulating cortex-wide networks during social behavior in autism spectrum disorder models. The funded research addresses cortical network dysregulation in autism by combining ultrasensitive dual-color...
- The National Institute of Neurological Disorders and Stroke awarded Miami University $539,920 on September 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate how TSC1 loss disrupts Purkinje neuron axon initial segment organization and cerebellar function in autism spectrum disorder. The research examines the cellular mechanisms by which TSC1 deletion in Purkinje neurons alters axon initial segment function and...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $395,009 to the University of California, Davis on August 1, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The two-year project, extending through July 31, 2027, supports foundational research to develop antisense oligonucleotide (ASO) therapy for ADNP syndrome (Helsmoortel-van der Aa syndrome), a severe...
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $1,179,715 on March 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to understand how nociceptors—somatosensory nerve fibers that detect noxious stimuli—detect, integrate, and transmit pain signals under various environmental and physiological conditions. The recipient will...
The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $117,747 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to examine SCN2A loss of function in sensory perception and its relationship to autism spectrum disorder pathophysiology. The project investigates how haploinsufficiency of SCN2A—the gene most strongly associated with autism spectrum disorder—disrupts sensory perception at the cellular, circuit, and behavioral level. The research combines two-photon calcium imaging of layer 5 pyramidal neuron dendrites with behavioral paradigms to test whether SCN2A haploinsufficient mice exhibit altered perceptual thresholds for whisker stimulation. The work also employs ex vivo acute slice preparations and in vivo two-photon calcium imaging to determine how SCN2A loss disrupts functional coupling between dendritic compartments and impairs dendritic integration. The objective is to define a novel mechanism by which SCN2A haploinsufficiency disrupts neocortical somatosensory function, modeling a key cellular mechanism underlying autism spectrum disorder-associated somatosensory dysfunction. Performance occurs in San Francisco, California from the award date through July 31, 2028. This is a mentored career development project grant (K99 mechanism), supporting the professional development of a postdoctoral researcher preparing for independent research leadership.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $117.7k | 8/11/26 |