Project Grant K99NS150832
- The National Institute of Neurological Disorders and Stroke awarded the University of California, San Diego $121,554 on February 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of tanycyte barriers at circumventricular organs in health and neuroinflammation. The project, titled "Investigating the Role of Tanycyte Barriers at the Circumventricular Organs in Health and Neuroinflammation," will...
- The National Institute of Neurological Disorders and Stroke, an institute of the National Institutes of Health, awarded The Regents of the University of California, San Francisco $205,200 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into the role of microglia in cortical interneuron development in genetic and environmental disruptions associated with autism spectrum disorder. The work...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, San Diego $119,286 on August 18, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the functional roles of microbial metabolites in HIV-associated neurocognitive disorders (HAND). The research integrates metabolomics, metagenomics, in vitro and in vivo assays, and computational approaches to address gaps in understanding...
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $190,080 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining the relationships between economic instability, epigenetic aging, and vascular contributions to cognitive impairment (VCID) across the adult lifecourse. The project applies causal inference methods...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Regents of the University of California, San Francisco $128,139 on September 23, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to develop a multi-modal transcriptomic atlas of normal and diseased cerebral vasculature, with focus on mural cell biology in brain arteriovenous malformations (BAVMs). The research consists of two...
- The National Institute of Neurological Disorders and Stroke awarded the University of California, San Diego $236,115 on August 28, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to examine the impact of cobalamin C deficiency in human brain development. The research investigates cobalamin C deficiency, one of the most common inborn errors of metabolism, which interrupts methionine remethylation and causes neonatal-onset...
- The National Institute of Neurological Disorders and Stroke awarded The Scripps Research Institute $710,155 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate post-transcriptional mechanisms of cortical inhibitory interneuron development. The research focuses on identifying how microRNA-mediated regulation controls interneuron migration and specification during development. The work employs engineered...
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $451,000 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant R21NS144615). The award funds development of genetic tools and methods for tracking brain lipids in vivo with subcellular precision. The recipient will create genetic approaches to tag lipid tails and track lipid...
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $2,656,684 on February 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to discover and validate gene therapy and biologic delivery vectors for central nervous system diseases using physiologically maintained deceased human cadavers as a discovery platform. The award funds development of an...
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of California, San Francisco $595,208 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing Project Grant R01NS148534). The award funds research investigating striatal synaptic plasticity mechanisms underlying cognitive dysfunction in Parkinson's disease. The project examines circuit- and synaptic-level...
The National Institute of Neurological Disorders and Stroke awarded the University of California, San Diego $121,554 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Program Grant K99NS150832). The award funds research investigating pericyte regulation of central nervous system metabolism and function. The project tests hypotheses that pericytes regulate the CNS metabolome and thereby influence neurovascular coupling and behavior through analysis of mutant mice exhibiting dysregulated metabolic gene expression. Specific aims include using metabolomics, two-photon imaging, and behavioral analysis to examine the role of Wnt/β-catenin signaling in pericyte metabolic regulation; investigating pericyte SLC6A13 (GABA transporter 2) function in CNS GABAergic signaling using conditional knockout mice and human pluripotent stem cell-derived CNS-like mural cells; and examining pericyte GATM function in phosphate shuttle metabolism. The research employs metabolomics, uptake assays, two-photon imaging, and behavioral analysis to evaluate hypothesized mechanisms. Performance occurs in La Jolla, California. The period of performance runs from September 1, 2026, through August 31, 2028. The award is assistance type Project Grant, representing the early-career K99/R00 transition phase of the NIH career development program structure.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $121.6k | 8/20/26 |