Project Grant K99NS142248
- This federal Project Grant award of $205,000, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), is funding research to elucidate the role of serotonergic and purinergic signaling pathways in mediating nociception (pain sensation) within the female reproductive tract. The project, titled "Pain Mechanisms in the Female Reproductive Tract", aims to characterize these...
- This federal Project Grant award of $517,494.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Duquesne University to define differentially expressed RNA splice isoforms of the transcription factor ATF3 that are responsible for sex-specific differences in pain and pain-relief. The research aims to provide a more comprehensive...
- This federal Project Grant award, valued at $238,276, was provided by the National Institute of Neurological Disorders and Stroke under the Drug Abuse and Addiction Research Programs (CFDA 93.279). The funding supports research at the University of California, Irvine to investigate the role of the enzyme N-acylethanolamine acid amidase (NAAA) in the development of hyperalgesic priming, a model for studying the transition from acute to chronic pain. The project aims to identify the receptor...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $421,437 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Regents of the University of Minnesota. The grant supports research to investigate sex differences in spinal dopaminergic mechanisms underlying neuropathic pain. The project aims to define the function of dopamine 1 receptors (DRD1) expressed in dorsal horn neurons and their role in nerve...
- This $453,104 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to explore independent ascending spinal pain circuits that transmit pain signals to the brain. The primary focus is on understanding the role of a newly identified subset of spinal projection neurons expressing the GPR83 neuropeptide receptor, in...
- This Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The $226,530 award will support a research project at the University of California, San Francisco (UCSF) focused on using brain stimulation to identify and test network biomarkers for chronic pain relief. The project aims to leverage advanced functional MRI,...
- This Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $233,088 to The Washington University to investigate the role of dorsal raphe nucleus enkephalin neurons in motivational and affective behaviors during chronic pain. The primary goal is to determine how endogenous opioids in the dorsal raphe nucleus contribute to the emotional component of chronic pain states. The research will use dual-color 1-photon endoscopic...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $444,125 in funding to Duke University to explore the role of the LRRC55 regulatory protein in pain pathways. The key objectives are to: 1) delineate LRRC55's function in chronic pain behaviors using genetically-modified mice, 2) quantify changes in LRRC55 expression in dorsal root ganglion and spinal cord neurons...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
- This federal Project Grant award of $222,758 from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), is funding research to map the functional roles of different neuron types in the dorsal root ganglia (DRG) and understand their contributions to pain perception in the brain. The primary awardee, the University of North Carolina at Chapel Hill (UNC-CH), will use innovative optogenetic and chemogenetic techniques to selectively...
This Project Grant award of $238,685 from the National Institute of Neurological Disorders and Stroke (CFDA 93.279 - Drug Use and Addiction Research Programs) supports research by the University of California, San Francisco (UCSF) to investigate sex-dependent modulation of pain pathways by regulatory T cells. The research aims to elucidate how sex hormones and pregnancy influence an opioid signaling circuit in the spinal cord meninges that confers antinociceptive effects in female mice. This includes examining the role of this neuroimmune pathway in increased pain sensitivity observed in female offspring of mothers with chronic pain. The research is structured as a K99/R00 award, with the initial K99 phase focused on understanding the hormonal regulation of this circuit in nulliparous mice, and the subsequent R00 phase exploring the impact on offspring pain sensitivity. The overall goal is to provide insights into the sex-specific mechanisms underlying chronic pain differences between men and women.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $238.7k | 7/31/25 |