The federal Project Grant award, titled "INVESTIGATING THE ROLE OF DORSAL RAPHE NUCLEUS ENKEPHALIN NEURONS IN MOTIVATIONAL AND AFFECTIVE BEHAVIORS DURING CHRONIC PAIN," is funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The primary goal of this $154,568 F32 award, with a performance period from June 12, 2025 to December 31, 2028, is to determine the contribution of endogenous opioids within the dorsal raphe nucleus to motivational and affective behavioral dysregulation during chronic pain. The research, conducted by The Washington University in St. Louis, will use various neuroscience techniques, such as dual-color one-photon endoscopic imaging and chemogenetics, to examine how enkephalinergic neurons in the dorsal raphe nucleus encode pain and motivated behaviors before and after the development of chronic pain. The findings are expected to provide insights into the role of endogenous opioids in the dorsal midbrain and identify potential neurochemical targets for therapeutic intervention in chronic pain.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $77.3k | 12/12/24 | ||
| Not listed | $0 | 12/12/24 | ||
| Not listed | $77.3k | 12/12/24 |