This $2,068,842 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to identify the role of prefrontal cortical dynorphin neuron activity and dynorphin release in modulating pain-induced negative affect and nociception. The research aims to use ex-vivo electrophysiology and in-vivo calcium imaging in mice to determine how pain influences the activity of...
This $650,079 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 aims to develop and optimize novel small-molecule probes targeting alpha9-containing nicotinic acetylcholine receptors (α9*-nAChRs) for the treatment of chronic inflammatory and neuropathic pain. Awarded to Northeastern University, the 5-year research project seeks to advance the understanding and therapeutic exploitation of α9*-nAChRs as a promising target for...
This Project Grant award, totaling $444,125 and awarded by the National Institute of Neurological Disorders and Stroke (NINDS), is funding research under the Drug Use and Addiction Research Programs (CFDA 93.279) to explore the function of the LRRC55 protein in pain transmission. The primary recipient, Duke University, will investigate the role of LRRC55 in regulating ion channels involved in chronic pain, with the goal of identifying novel, non-opioid therapeutic targets to treat pain. Key...
This $838,750 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to investigate the role of the GCH1 gene and its encoded enzyme GTP cyclohydrolase 1 (GTPCH1) in chronic orofacial neuropathic pain. The award, provided to the University of Florida, will fund preclinical studies using an operant orofacial pain assay and chronic constriction injury model in rats...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $453,104 to The University of Texas Southwestern Medical Center to conduct research on the role of specific spinal projection neurons in chronic pain. The research aims to explore the functional redundancy between two main subtypes of these neurons, those expressing TACR1...
This federal Project Grant award for $173,799.00 was provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279). The award aims to investigate the role of the endogenous opioid system in pain perception and placebo analgesia (pain relief) at the cellular and neural circuit levels in the ventrolateral periaqueductal gray (VLPAG) and ventral tegmental area (VTA) regions of the midbrain. The research will utilize advanced in vivo...
This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research into a novel, non-opioid spinal analgesic mechanism for the treatment of high-impact chronic pain. The $664,772 award to the University of Texas Southwestern Medical Center aims to dissect the signaling pathway involving the neurotensin receptor 2 (NTSR2)...
This $2,569,851 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Abuse and Addiction Research Programs (CFDA 93.279), supports research to investigate how the PD-L1/PD-1 immune checkpoint pathway controls physiological and pathological pain, as well as opioid analgesia, through neuronal, immune, and glial mechanisms. The project aims to validate the actions of PD-L1 and the checkpoint inhibitor nivolumab on neuroinflammation and...
This National Institute on Drug Abuse (NIDA) Project Grant award under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $154,568 to The Washington University in St. Louis to investigate the role of enkephalin neurons in the dorsal raphe nucleus on motivational and affective behaviors during chronic pain. The primary goal is to determine how endogenous opioids in this brain region contribute to the emotional and motivational dysfunction observed in chronic pain conditions....
This $2,249,392 Project Grant was awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Leland Stanford Junior University. The project aims to validate cellular senescence as a target for treating chronic pain in aging populations. Specifically, the research will leverage multiple clinically-relevant mouse models and human post-mortem tissue to characterize the role of senescent neurons and their...