Project Grant K99HD120651
- The National Institute of Child Health and Human Development awarded the University of California, San Diego $153,560 on December 1, 2026, under the Child Health and Human Development Extramural Research Program (CFDA 93.865) to investigate gene regulatory mechanisms driving totipotency induction in human stem cells. The research examines how RNA splicing dysfunction alters early human development through integrative transcriptomic, epigenomic, and proteomic profiling. The work focuses on...
- The National Institute of Child Health and Human Development awarded $430,375 to the University of California Santa Cruz on August 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the role of RNA-modifying enzymes in regulating totipotent gene expression during early embryonic development. The research explores how the putative RNA methyltransferase METTL7A1 regulates zygotic genome activation and totipotency in mouse...
- The National Institute of Child Health and Human Development awarded Yale University $1.396 million on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate centromere integrity and cytoskeletal function in oocyte aneuploidy and reproductive aging. The award funds research using mouse oocytes to analyze how centromere proteins (including CENP-A and CENP-C), centromeric DNA composition, and microtubule-associated proteins interact to...
- The National Institute of Child Health and Human Development awarded The Regents of the University of California, San Francisco $500,000 on September 1, 2026, under the Child Health and Human Development Extramural Research grant program (CFDA 93.865) to conduct single-cell molecular characterization and computational drug discovery for fertility-sparing treatment of uterine fibroids. The project applies single-nucleus RNA sequencing and computational drug-repurposing methods to identify...
- The National Institute of Child Health and Human Development awarded The Washington University $922,870 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR). The award funds research to define the molecular mechanisms by which age-associated increases in ovarian tissue stiffness drive follicle inflammation and impair oocyte quality and fertility. The research tests the hypothesis that follicles detect age-related...
- The National Institute of Child Health and Human Development awarded the University of Southern California $347,919 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865, Assistance Listing 93.HDR) to decipher the role of RG motifs in piRNA-mediated silencing and transgenerational fertility. The research investigates how arginine/glycine (RG) motifs in PIWI-interacting RNA (piRNA) pathway proteins PRG-1 and HRDE-1 regulate germline gene expression...
- The National Institute of Child Health and Human Development awarded the Buck Institute for Research on Aging $194,000 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate ovarian aging through the three-dimensional lymphatic network. The research examines how the lymphatic vasculature contributes to ovarian function across adulthood and aging, with focus on three-dimensional lymphatic structure and function and...
- The National Institute of Child Health and Human Development awarded Northwestern University $240,000 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.HDR) to develop ovarian somatic organoids as a drug discovery model for reproductive longevity. The research addresses ovarian aging, characterized by loss of egg quantity and quality leading to infertility and altered endocrine function. The funded work builds on the recipient's...
- The National Institute of Child Health and Human Development awarded The University of Texas Southwestern Medical Center $682,848 on June 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate mitochondrial function and quality control in germ cell development and reproductive aging. The award funds basic biomedical research using a novel enforced mitophagy platform to modulate mitochondrial abundance and quality in vivo across specific...
- Federal Project Grant Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $425,628 project grant to the Regents of the University of California at Riverside on August 1, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports a two-year research initiative (through July 31, 2027) investigating the molecular mechanisms by which mutations in the Fragile X Messenger Ribonuclein 1...
The National Institute of Child Health and Human Development awarded The Regents of the University of California, San Francisco $123,147 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds research investigating granulosa-derived RNAs as targets for oocyte rejuvenation and age-related oocyte quality infertility. The project comprises three aims: interrogating the mechanism by which RNAs transfer from granulosa cells to oocytes through vesicle trafficking or membrane fusion; using in vivo transgenic approaches to identify which mRNAs transfer and in what quantity to support oocyte growth stages; and developing a protocol to supplement oocytes with in vitro transcribed RNAs to improve maturation outcomes in human and mouse germinal vesicle stage oocytes. The research plan characterizes the mechanistic cell biology of granulosa-derived RNA support and develops interventions for oocyte quality-related infertility patients. Performance occurs at the University of California, San Francisco, San Francisco, California 94143, with a period of performance from September 1, 2026, through August 31, 2028. The award is classified as a Project Grant, providing support for hypothesis-driven biomedical research under the program's mission to lead research and training on human development and reproductive health.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $123.1k | 8/18/26 |