This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support research to characterize the structural and functional properties of Cadherin EGF Laminin G Seven-Pass G-Type Receptors (CELSRS), an understudied group of cellular adhesion proteins. The $108,793 award, effective January 1, 2025 through December 31, 2026, will enable the University of Chicago to improve the cryo-EM reconstruction of the CELSR1 extracellular region, test disease-associated variants, and conduct a proximity labeling screen to identify novel binding partners of the CELSR1 intracellular region. This research aims to elucidate the mechanisms by which CELSR function is regulated and how dysregulation can contribute to developmental disorders. The project will be carried out by the awardee, with support from expert mentors in cryo-EM, GPCR signaling, and proximity labeling techniques.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $108.8k | 12/27/24 |