This $300,477 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859). The award will support a 5-year research project focused on investigating the molecular regulation of cell protrusion function in 3D environments. The research aims to develop computational algorithms based on computational geometry to reconstruct plasma membrane organization from 3D microscopy images and...
The National Institute of General Medical Sciences (NIGMS) awarded a $366,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Central Michigan University. The grant, which runs from January 1, 2025 to December 31, 2029, aims to develop bioluminescent kinase sensors to monitor and manipulate cell signaling processes related to cell growth, division, and the cell cycle. The proposed research seeks to create novel tools for studying cell biology and...
The National Institute of General Medical Sciences (NIGMS) awarded a $153,656 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Fred Hutchinson Cancer Center in Seattle, WA. The funding supports research to understand how post-translational modifications, specifically ubiquitin, contribute to kinetochore assembly and function in the budding yeast Saccharomyces cerevisiae. The research aims to generate a comprehensive map of kinetochore regulation by...
The National Institute of General Medical Sciences (NIGMS) awarded a $528,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research located in New York, NY. The purpose of this 4-year grant, with a period of performance from September 30, 2024 to July 31, 2028, is to develop novel approaches to map the folding and protein occupancy of entire chromosomes with single-nucleosome resolution and single-molecule precision. The...
The National Institute of General Medical Sciences (NIGMS) awarded a $925,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to St. Jude Children's Research Hospital Inc. The grant supports a multidisciplinary research program to discover chemical modulators of RNA-protein assemblies, with a focus on targeting Dead-box RNA-dependent ATPases. The project aims to identify allosteric compounds that stabilize Dead-box protein-RNA interactions, optimize...
This Project Grant award for $125,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program, supports research to investigate the role of protein N-myristoylation in the DNA damage response (DDR) and its impact on genomic stability. The key objectives of this award are to: 1) Assess the association between N-myristoylation, modulated by NMT1 and NMT2, and DDR pathways, including the impact on DNA...
The National Institute of General Medical Sciences (NIGMS) awarded a $440,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research in New York. The 5-year grant, awarded on February 3, 2025, supports advanced research to decode the ubiquitin and autophagy signaling networks, which are essential cellular processes involved in proteome homeostasis. The research program combines expertise in quantitative mass spectrometry,...
This Project Grant award of $179,736.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on the post-translational regulation of norad-induced pumilio phase separation. The project aims to investigate how phosphorylation of the RNA-binding protein pumilio1 (PUM1) dynamically regulates the formation and dispersal of biomolecular condensates, known as norad-pumilio (NP) bodies, during the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $350,635.00 in funding to the Regents of the University of Minnesota to develop new fluorescent aptamer tags for visualizing RNA in complex biological systems. The project aims to select fluorescent aptamers that do not form G-quadruplex structures, which can impair the use of aptamers as RNA imaging tags, particularly in...
The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded a $355,584 Project Grant to the New Mexico Institute of Mining and Technology (New Mexico Tech) on August 18, 2023. This funding will support research to determine the biochemical basis and functional implications of the interaction between the proteins XRN2 and DDX23, and explore their cooperative role in regulating RNA-DNA hybrid structures...