This $320,053 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support comprehensive research on craniofacial connective tissue development and its role in craniofacial disorders. The award recipient, the University of Southern California, will leverage expertise in craniofacial biology to investigate the molecular mechanisms regulating the assembly and maintenance of...
This federal Project Grant award, totaling $682,663.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award is aimed at supporting research on understanding the role of fibronectin-directed cell migration in the growth and development of the calvarial bones, which are critical for proper skull formation. The research, conducted by Case Western Reserve University (CWRU), seeks to...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $294,000 over a 2-year period from September 2024 to September 2026. The objective is to advance the understanding of craniofacial cartilage differentiation from human neural crest stem cells in 3D cell culture models. The research aims to develop methods for generating functional, transplantable craniofacial cartilage...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $302,318 Project Grant under the Oral Diseases and Disorders Research Program (CFDA 93.121) to Rutgers, The State University. The grant will fund research to investigate the effects of skull malformations and intracranial hypertension on the glymphatic and meningeal lymphatic systems in craniosynostosis. Key aims include testing if impaired glymphatic (cerebrospinal fluid) influx and efflux impedes the clearance of...
This federal Project Grant award for $148,176.00, awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Program (CFDA 93.121), will fund research to uncover novel gene regulatory networks underlying specialized craniofacial development in a new model system of pupfishes. The study will combine tissue-specific differential gene expression analysis and genome-wide chromatin accessibility studies across three developmental...
This federal Project Grant award (R21DE033851) is provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant will establish the Human Craniosynostosis Atlas (HUCA), a publicly accessible repository that will gather and standardize comprehensive CT, MRI, and genomic data on infants with various forms of craniosynostosis, a premature fusion of the cranial sutures. The $550,810 award, with a...
This Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Department of Health and Human Services, will fund research into the genetic basis of human skeletal facial morphology through July 2025. Provided under the Oral Diseases and Disorders Research program (CFDA 93.121), the $936,510 in funding will support two key aims. First, the awardee will enhance current mesh landmarking procedures for craniofacial bone by developing a dense quasi-landmark...
This $2,055,996 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund a research program led by Dr. Noriaki Ono at the University of Texas Health Science Center at Houston (UTHealth) to investigate skeletal stem cell plasticity in craniofacial bone diseases. The research program consists of three interconnected projects: Examining the roles of periosteal and endosteal stem cells...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) totals $658,530 and runs from June 1, 2024 to May 31, 2029. The grant supports research to develop a mesenchymal stromal/stem cell (MSC) implantation therapy as a treatment for neurocognitive deficits associated with craniosynostosis, a congenital disorder characterized by premature...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $130,122 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of North Carolina at Chapel Hill (UNC-CH). The project, titled "Investigating the Roles of the H3K4 Methyltransferases KMT2C and KMT2D in Chondrocyte Differentiation and Endochondral Ossification," will leverage genomic methodologies to examine the molecular mechanisms by which the...
The federal Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), is supporting a comprehensive investigation into the regulatory mechanisms underlying meningeal development and cranial tumorigenesis. The $162,281 award, effective from April 7, 2025 to March 31, 2027, will enable researchers at the California Institute of Technology (Caltech) to leverage advanced single-cell multi-omics, live imaging, and tissue-specific ablation techniques to dissect the spatiotemporal heterogeneity and plasticity of the cranial meninges. This work aims to functionally characterize the gene regulatory networks involved in meningeal development and determine the developmental gene regulatory programs activated in cranial meningiomas. The research findings have the potential to enhance understanding of craniofacial biology and inform the development of novel therapeutic approaches for meningioma treatment.