The University of Southern California (USC) has been awarded a $658,530 Project Grant under the National Institute of Neurological Disorders and Stroke (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The 5-year grant, effective June 1, 2024, will support research to establish novel mechanisms and a therapeutic strategy using mesenchymal stromal/stem cell (MSC) implantation to reduce intracranial pressure and reverse neurological deficits in patients with the craniofacial disorder craniosynostosis. Building on the grantee's previous work, the research aims to identify and correct defects in meningeal lymphatic vessels and cerebral veins that contribute to the brain structure and function abnormalities observed in this condition. The goal is to provide preclinical validation of MSC implantation as a viable alternative to the current highly invasive surgical treatments for craniosynostosis-related brain deficits.
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