The federal Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), is supporting a comprehensive investigation into the regulatory mechanisms underlying meningeal development and cranial tumorigenesis. The $162,281 award, effective from April 7, 2025 to March 31, 2027, will enable researchers at the California Institute of Technology (Caltech) to leverage advanced single-cell...
This federal Project Grant award, totaling $682,663.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The award is aimed at supporting research on understanding the role of fibronectin-directed cell migration in the growth and development of the calvarial bones, which are critical for proper skull formation. The research, conducted by Case Western Reserve University (CWRU), seeks to...
This $320,053 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support comprehensive research on craniofacial connective tissue development and its role in craniofacial disorders. The award recipient, the University of Southern California, will leverage expertise in craniofacial biology to investigate the molecular mechanisms regulating the assembly and maintenance of...
This federal Project Grant award (R21DE033851) is provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant will establish the Human Craniosynostosis Atlas (HUCA), a publicly accessible repository that will gather and standardize comprehensive CT, MRI, and genomic data on infants with various forms of craniosynostosis, a premature fusion of the cranial sutures. The $550,810 award, with a...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $455,939 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Massachusetts Lowell. The 3-year project, which commenced on July 1, 2024, will investigate the molecular and cellular mechanisms underlying the effects of the signaling factor FGF8 on the development and morphogenesis of the first pharyngeal pouch and first pharyngeal cleft, which are critical for proper jaw...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under CFDA 93.121 - Oral Diseases and Disorders Research provides $453,750 in funding to Trustees of Boston University to conduct research on the genetic and cellular mechanisms underlying craniosynostosis, a common craniofacial birth defect. The research aims to discover how reduced expression of the ERF transcription factor contributes to the development of craniosynostosis by examining genome-wide...
This federal Project Grant award of $2,461,369.00, awarded by the National Institute on Aging (part of the Department of Health and Human Services) under the Aging Research Federal Grant Program (CFDA 93.866), aims to establish mechanisms for rejuvenating brain lymphatics and exploit brain lymphatic activation as a new therapeutic strategy for craniosynostosis and Alzheimer's disease. The key products and services to be delivered under this 3-year grant include: Developing an animal model...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $294,000 over a 2-year period from September 2024 to September 2026. The objective is to advance the understanding of craniofacial cartilage differentiation from human neural crest stem cells in 3D cell culture models. The research aims to develop methods for generating functional, transplantable craniofacial cartilage...
The National Institute of Dental and Craniofacial Research (NIDCR), part of the Department of Health and Human Services, awarded a $847,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Utah. The 2-year grant, awarded on August 1, 2023, will fund research to develop and evaluate the efficacy of a novel antimicrobial bone scaffold made from zinc-doped fluorapatite for use in craniofacial surgical applications. The research aims to...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to establish a novel zebrafish model to study the pathomechanisms underlying syndromic craniosynostosis, a common craniofacial birth defect. The award totaling $313,000 will be used to conduct comprehensive phenotypic, mechanistic, and genetic analyses of a unique zebrafish mutant that exhibits features of severe syndromic...