This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $608,632.33 to investigate the role of tuft cells in salivary gland immunity. The key objectives are to: 1) Explore tuft cell distribution and function in salivary gland epithelium; 2) Determine tuft cell chemosensory components; and 3) Assess the effects of tuft cell ablation on salivary gland innate immunity....
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $628,965 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Icahn School of Medicine at Mount Sinai. The grant aims to elucidate how immune cells, specifically tissue-resident macrophages, regulate the coordinated processes of salivary gland epithelial cell development and differentiation. Using genetic mouse models and transcriptomic approaches, the project will determine how...
This federal Project Grant award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop advanced artificial mucin substitutes that can closely replicate the physiological functions of natural salivary mucins. The total award amount is $491,193, with a project period from September 1, 2024 to August 31, 2025. The key objectives are to: (1) craft artificial mucins that mirror the...
This R21 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will support research to determine the impact of cellular senescence on Sjögren's syndrome (SS)-associated salivary gland dysfunction and stem cell activity. The $248,750 project, awarded to the ADA Forsyth Institute, Inc. (The Forsyth Institute) in Cambridge, MA, aims to elucidate the role of cellular senescence in SS-related...
This $231,492 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop the first-ever in vitro Salivary Gland Sjogren's Syndrome Tissue Chip (SSTC) platform. The SSTC will utilize microbubble array technology and the MRL/lpr mouse model to investigate the effects of endocrine-disrupting chemicals on the growth and function of salivary gland tissue mimetics. The project will...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), provides $1,487,286 to the University of Wisconsin-Madison to define how different endotypes of Sjögren's disease modify the immunobiology of salivary gland mesenchymal stromal cells (SG-MSCs). The goal is to elucidate the pathogenic contributions of SG-MSCs in Sjögren's disease, a common autoimmune condition...
This three-year, $562,067 National Science Foundation Project Grant funds the development of an engineered salivary gland tissue model at the University of Delaware from April 2023 to March 2026. The model aims to simulate salivary gland fibrosis using cells isolated from human salivary glands and connective tissue grown within a customizable synthetic extracellular matrix. Researchers will study how changes to the matrix induce fibrosis and alter epithelial cell function, with the goal of...
This Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will support the development of a bio-inspired scaffold (referred to as "PerioPatch") for regenerating Sharpey's fibers and periodontal tissues. The $588,952 award, effective April 18, 2025 through March 31, 2030, aims to integrate crucial biophysical and biochemical cues into a matrix to guide periodontal...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $260,375 to the University of California, Los Angeles (UCLA) to develop and validate a saliva-based assay for the early detection of Sjögren's disease (SJD) and autoimmune-sicca syndrome (AI-sicca). The key products and services to be delivered include: Acquiring and characterizing clinical cohorts of SJD, AI-sicca,...
The Research Foundation for the State University of New York (RF-SUNY) has been awarded a $300,000 "Trans-NIH Research Support" Project Grant (CFDA 93.310) from the National Institutes of Health (NIH) Office of the Director. The purpose of this 1-year award, effective September 1, 2023, is to investigate the role of cellular senescence and associated inflammatory signaling (the senescence-associated secretory phenotype or SASP) in promoting salivary gland dysfunction in Sjogren's...