Project Grant R01DA062710
- Federal Grant Award Summary The University of Pennsylvania received a $1.56M Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research investigating the role of central amylin receptors in opioid-mediated behaviors. The five-year project, initiated July 1, 2025 and concluding March 31, 2030, will deliver research findings and scientific knowledge addressing the critical public health challenge of...
- Federal Grant Award Summary The University of Pennsylvania received a $247,702 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded July 31, 2025, with completion expected January 31, 2028. This award supports a neuroscience research project investigating the role of mu-opioid receptors in the paraventricular nucleus of the thalamus (PVT) in the development of stress-related behavioral phenotypes and their...
- Federal Grant Award Summary The University of Pennsylvania received a $454,251 Project Grant awarded July 15, 2025, by the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop innovative diagnostic and monitoring tools for opioid use disorder research. The project, extending through June 30, 2027, focuses on creating a device-free blood-based biomarker detection system called Released Markers of Activity (RMAs) to enable long-term...
- Federal Project Grant Award Summary The University of Pennsylvania received a $667,349 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, through June 30, 2030. This award funds research investigating state-dependent control of nociception in opioid circuits, specifically examining how pain perception is modulated by...
- Federal Grant Award Summary Award Details: Drexel University received a $832,132 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded on March 1, 2026, with completion scheduled for February 29, 2028. Research will be conducted at the awardee's Philadelphia, Pennsylvania facility. Research Deliverables: This award supports basic neuroscience research investigating novel circuit mechanisms underlying...
- This National Institutes of Health National Institute on Drug Abuse Project Grant award of $234,364.35 supports research from March 1, 2021 through August 31, 2022 at clinical practices of the University of Pennsylvania located in Pennsylvania. The research aims to characterize a nociception-active basolateral amygdala to anterior cingulate cortex circuit that contributes to affective-attention pain behaviors, and determine its overlap with endogenous mu opioid receptor systems. The grant also...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Johns Hopkins University a $466,363 Project Grant effective June 1, 2026 through April 30, 2031 under the Drug Use and Addiction Research Programs (CFDA 93.279). This award supports fundamental research to characterize and exploit allosteric crosstalk among pain receptors, specifically examining how endogenous neuromodulators such as endocannabinoids and oxytocin allosterically modulate mu-opioid receptor (MOR)...
- Federal Grant Award Summary The University of Pittsburgh received a $129,330 Project Grant from the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning June 15, 2026, with completion expected by May 31, 2028. This award supports fundamental neuroscience research investigating spinal neural circuits involved in pain modulation and the mechanisms by which chronic stress amplifies pain processing. The research employs...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The University of Pennsylvania a $446,875 Project Grant effective June 1, 2025, through May 31, 2027, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The research project focuses on generating and characterizing a novel NTRK3-FLPO knockin mouse line to enable genetic interrogation of Aβ nociceptors—a previously inaccessible population of...
- Federal Grant Award Summary American University received a $476,496 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning August 15, 2025, and concluding July 31, 2028. The grant funds fundamental neuroscience research investigating opioid signaling mechanisms in reward-guided decision-making within the rat prefrontal cortex, specifically the prelimbic area. The research employs a two-alternative forced choice...
The University of Pennsylvania received a $708,040 Project Grant awarded June 15, 2026, by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research on distinct amygdalar neural circuits underlying pain and opioid dependence. The research project, extending through March 31, 2031, will investigate how chronic opioid exposure induces neural plasticity in brain circuits critical to pain processing and defensive responses, with particular focus on the parabrachio-amygdalar pathway. The research employs a fentanyl dependence mouse model compatible with postoperative pain assessment, utilizing advanced methodologies including in vivo calcium imaging, single-nuclei RNA sequencing, and functional neural circuit manipulations to characterize hyperexcitability in opioid-dependent states. This project addresses critical knowledge gaps regarding opioid-induced hyperalgesia (OIH), withdrawal syndrome, and opioid use disorder (OUD) by examining how mu-opioid receptors on specific glutamatergic neurons contribute to enhanced defensive and pain responses following chronic opioid exposure. The deliverables will include characterization of neural circuit activation patterns during opioid withdrawal, identification of molecular and cellular mechanisms driving hyperexcitability in amygdalar regions, and mechanistic insights into how circuit-level changes contribute to opioid dependence behaviors. These research outputs will generate fundamental neuroscience knowledge intended to inform development of targeted therapeutic interventions for managing opioid dependence and associated pain complications.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $708.0k | 6/12/26 |