Project Grant R01DA064823
- The National Institute on Drug Abuse awarded Washington State University $420,750 on July 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the neurobiological substrates of cannabis-seeking behavior through preclinical research models. The funded research combines fiber photometry and wireless recording techniques to examine how dynamic neural activity and dopamine release in corticostriatal circuits—specifically the medial prefrontal cortex and nucleus...
- The National Institute on Drug Abuse awarded the University of Washington $100,228 on November 10, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to characterize the role of endogenous nociceptin opioid release from the central amygdala in reward outcome encoding. The recipient will conduct research examining how nociceptin-containing neurons in the central amygdala engage distinct reward properties—including reward probability and size—and project to the lateral...
- The National Institute on Drug Abuse awarded the University of California, San Diego $165,669 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to identify behavioral and neural markers of opioid withdrawal-induced risk-taking and their relationship with relapse vulnerability. The research establishes and validates a translatable rodent model of opioid withdrawal to explore cognitive factors linked to relapse. The project uses the rat Iowa Gambling Task to...
- The National Institute on Drug Abuse awarded Wayne State University $149,766 under the Drug Use and Addiction Research Programs (CFDA 93.279) on August 11, 2026, to conduct translational research examining perinatal exposure to concomitant opioid medications and antidepressants in a rodent model. The research investigates effects on the maternal brain, behavior, and offspring neurodevelopment, addressing a significant gap in understanding how medications for opioid use disorder (such as...
- The National Institute on Drug Abuse awarded The Washington University $682,262 on August 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct basic research on the role of locus coeruleus mu opioid receptors in fentanyl-seeking behaviors. The research investigates how endogenous opioid receptors in the locus coeruleus control fentanyl self-administration and contribute to opioid reward and reinstatement of fentanyl seeking. The work employs conditional...
- The University of Washington was awarded a $149,284 Project Grant by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of specific subpopulations of prefrontal cortex pyramidal neurons in regulating drug-seeking behavior. The research aims to elucidate the factors that predispose individuals to addiction and confer vulnerability to relapse, with the goal of advancing understanding of the functional roles of...
- The National Institute on Drug Abuse (NIDA) awarded a Cooperative Agreement of $733,457 to The Washington University on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds research investigating the long-term neurodevelopmental impact of maternal opioid exposure and opioid management strategies in rodent offspring. The project evaluates how in utero oxycodone exposure, maintenance therapy with methadone and buprenorphine, and withdrawal mitigation...
- The National Institute on Drug Abuse awarded the University of Southern California $108,000 on February 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the molecular mechanisms of a kappa opioid receptor selective negative allosteric modulator as a potential therapeutic approach to opioid addiction and overdose. The research seeks to elucidate the structural and functional basis of kappa opioid receptor modulation through negative allosteric...
- The National Institute on Drug Abuse awarded the Regents of the University of Michigan $595,171 on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate functional anatomy, physiology, and behavioral responses mediated by mu opioid receptor signaling on medial thalamic neurons. The research addresses opioid withdrawal-induced hyperalgesia (OWIH)—exaggerated pain perception that occurs when opioid-dependent individuals discontinue use. The project uses...
- The National Institute on Drug Abuse awarded Washington State University $639,915 on February 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to interrogate the mechanistic underpinnings of cognitive inflexibility in cannabis-exposed offspring. The research employs a novel, translationally relevant model of cannabis vapor exposure in pregnant rat dams, using custom-designed equipment to deliver discrete puffs of vaporized, plant-derived cannabis extracts in a...
The National Institute on Drug Abuse awarded Washington State University $604,683 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to dissect the role of thalamic withdrawal-encoding ensembles in opioid use disorder through basic neuroscience research. The recipient will employ viral trap technology and multilevel circuit-based approaches—including ex vivo electrophysiology, optogenetics, in vivo calcium imaging, and fiber photometry—to characterize the real-time activity dynamics of paraventricular thalamus neurons encoding spontaneous versus naloxone-precipitated withdrawal during cue-induced heroin seeking. The work uses a heroin self-administration model to systematically compare circuit mechanisms engaged by distinct neuronal ensembles and to identify therapeutic targets that may disrupt the withdrawal-relapse cycle perpetuating opioid use disorder. Performance runs through May 31, 2031, at Washington State University in Pullman, Washington. This is a Project Grant, the standard NIH assistance type for individual research projects. The funding supports basic research aligned with NIDA's mandate to develop new knowledge and approaches for the prevention, diagnosis, and treatment of drug use, misuse, and addiction.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $604.7k | 8/3/26 |