Project Grant K99AR085752
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to advance the understanding of muscle-subtendon units and their role in Achilles tendinopathy. The $666,825 award to the University of Delaware will fund a 5-year research study using advanced in vivo techniques such as MRI, ultrasound, and biomechanical assessments. The key objectives are...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is providing $1,958,125.00 to the University of Oregon to develop an innovative nanoparticle drug delivery system to improve tendon regeneration following acute injuries. The researchers aim to leverage a novel peptide that specifically targets and binds to inflammation markers in healing...
- This $360,580 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to develop an engineered extracellular matrix (EECM) that can promote regenerative healing in tendons. The University of Oregon will fabricate anisotropic PEG hydrogel-based EECM scaffolds and evaluate their ability to guide the alignment and matrix deposition of human...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $230,000 in funding to the Rochester Institute of Technology (RIT) to advance understanding of articular cartilage, the soft tissue covering the ends of bones in joints. The collaborative research project will examine how cartilage responds to physical forces relevant to daily activities like walking and jumping, with a focus on understanding how it responds to shear forces during...
- The National Science Foundation awarded a $750,000 Project Grant to Rutgers, The State University under the Engineering program (CFDA 47.041) from September 1, 2022 to August 31, 2025. The grant funds research to develop an injectable nanoparticle therapy to restore strength and length to damaged tendons and ligaments. Specifically, the university will investigate combining a thermosensitive polymer and crosslinking agent to stabilize joints by quickly strengthening and returning tissues like...
- This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $589,176.00 to the University of Rochester to conduct research on understanding the distinction between healthy and harmful tendon impingement. The research aims to determine why tendon impingement, a common occurrence where tendons encounter compressive forces from physical contact with bone, can sometimes trigger pathological responses in tendons. The key objectives are to...
- This NIH Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $308,927 to Tensense LLC to develop and evaluate an intraoperative device that directly measures ligament engagement during total knee arthroplasty. The key products to be delivered are: Integration of a handheld ligament tensiometer into a custom joint distractor to create an "integrated distraction tensiometer" device. This device will be calibrated and evaluated...
- This $556,160 Project Grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (CFDA 93.846) aims to examine the efficacy of a rehabilitation approach called Rehabilitation with Exercise and Psychological Support (REPS) for patients who have undergone ACL reconstruction surgery. The REPS intervention integrates standard exercise rehabilitation with psychological support, including clinician training, patient education videos, and techniques like...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support the development of an innovative self-powered smart piezoelectric total knee arthroplasty (TKA) implant platform. The $679,995 award to Tennessee Technological University will enable continuous in vivo measurement of joint kinematics and compartmental joint kinetics to address...
- This $1,024,510 National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases project grant funds research at the University of California, San Francisco into simultaneous imaging of tissue biochemistry and metabolism associated with biomechanics in patellofemoral joint osteoarthritis. The research will conduct a longitudinal cohort study of 100 individuals with isolated patellofemoral joint osteoarthritis followed over two time points. Simultaneous positron...
ADVANCING REHABILITATION OF PATELLAR TENDON INJURIES USING INNOVATIVE WEARABLE TECHNOLOGY AND QUANTITATIVE MAGNETIC RESONANCE IMAGING TECHNIQUES - ABSTRACT MY CAREER GOAL IS TO OPTIMIZE REHABILITATION, IMPROVE TREATMENT OUTCOMES, AND MITIGATE THE DEBILITATING LONG-TERM CONSEQUENCES FROM LOWER EXTREMITY TENDON INJURIES. IN THIS STUDY I PROPOSE TO ENHANCE THE TREATMENT FOR PATELLAR TENDON INJURIES. THE PATELLAR TENDON IS A KEY STRUCTURE FOR FORCE TRANSMISSION, MOBILITY, AND LOCOMOTION. THE BEST EVIDENCE-BASED TREATMENT FOR TENDON INJURIES INVOLVES TENDON LOADING VIA EXERCISE; HOWEVER, ESTABLISHING OPTIMAL DOSING REMAINS A CHALLENGE. CLINICAL TRIALS HAVE PRESCRIBED EXERCISES ASSUMING EXTERNAL LOADS SERVE AS SURROGATES FOR TENDON LOAD, HOWEVER, THIS ASSUMPTION IS NOT ENTIRELY ACCURATE DUE TO COMMONLY OBSERVED COMPENSATIONS AT ADJACENT JOINTS IN PATIENTS WITH KNEE INJURIES. THUS, METHODS TO DIRECTLY MEASURE TENDON LOAD ARE NEEDED. SHEAR WAVE TENSIOMETRY (SWT) IS A CLINICALLY FEASIBLE, WEARABLE TECHNOLOGY THAT CAN DIRECTLY MEASURE TENDON LOAD IN-VIVO. NEUROMUSCULAR ELECTRICAL STIMULATION (NMES) DURING EXERCISE IS A PROMISING APPROACH THAT MAY IMPROVE OUTCOMES BY AUGMENTING TENDON LOAD, YET ITS DIRECT EFFECTS ON TENDON LOAD HAVE NOT BEEN QUANTIFIED DUE TO LACK OF INNOVATIVE TECHNOLOGY TO STUDY THE EFFECTS. CURRENT METHODS FOR ASSESSING RECOVERY FROM TENDON INJURIES ARE ALSO INSUFFICIENT FOR ACCURATELY CAPTURING EFFECTIVENESS OF TREATMENTS. TENDON PATHOLOGY OBSERVED AT THE MACROSTRUCTURAL LEVEL DOES NOT ALWAYS RELATE WITH SYMPTOMS, AND IMPROVEMENTS IN SYMPTOMS TEND TO PRECEDE CHANGES TO TENDON MACROSTRUCTURE. DIFFUSION TENSOR IMAGING (DTI), A MAGNETIC RESONANCE IMAGING BASED METHOD TO MEASURE TENDON MICROSTRUCTURE IN-VIVO, OFFERS POTENTIAL TO BETTER STUDY TENDON PATHOPHYSIOLOGY AND TREATMENT RESPONSE. THIS PROJECT AIMS TO CAPTURE TENDON ADAPTATIONS AT THE MICROSTRUCTURAL LEVEL USING DTI IN RESPONSE TO A REHABILITATION PROGRAM FOCUSED ON TENDON LOADING QUANTIFIED VIA SWT AND ENHANCED BY NMES. TWO PATELLAR TENDON INJURIES WILL BE STUDIED: PATELLAR TENDINOPATHY AND BONE-PATELLAR TENDON- BONE AUTOGRAFT HARVEST FOR ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION. AIM 1 WILL ESTABLISH DTI METHODOLOGY TO QUANTIFY PATELLAR TENDON MICROSTRUCTURE AND THE RELATIONSHIP WITH KNEE FUNCTION IN PATIENTS WITH PATELLAR TENDON INJURIES. AIM 2 WILL QUANTIFY PATELLAR TENDON LOADS USING SWT DURING KEY REHABILITATION EXERCISES WITH AND WITHOUT NMES IN PATIENTS WITH PATELLAR TENDON INJURIES AND IN A HEALTHY COHORT. WE WILL RANK TENDON LOADS DURING EXERCISES AND COMPARE THE RANKINGS BETWEEN PATIENTS WITH PATELLAR TENDON INJURIES AND HEALTHY CONTROLS. THE ABILITY OF NMES TO AUGMENT TENDON LOAD WILL ALSO BE STUDIED. LASTLY, AIM 3 WILL DEVELOP AND DETERMINE THE PRELIMINARY EFFICACY OF A SWT-INFORMED REHABILITATION PROTOCOL AND QUANTIFY THE TREATMENT EFFECTS USING DTI IN PATIENTS WITH PATELLAR TENDINOPATHY. IN A 12-WEEK CLINICAL TRIAL, WE WILL ASSESS IMPROVEMENTS IN PATIENT SYMPTOMS AND FUNCTION, AND IF DTI CAN CAPTURE ACUTE MICROSTRUCTURAL CHANGES IN RESPONSE TO TREATMENT. THROUGH THE K99/R00 AWARD, I WILL GAIN THE QUALIFICATIONS AND PRELIMINARY DATA NECESSARY TO INDEPENDENTLY LEAD RANDOMIZED CONTROLLED TRIALS. THIS RESEARCH PROPOSAL IS EXPECTED TO BROADLY IMPACT TENDON INJURY REHABILITATION, POTENTIALLY IMPROVING TREATMENT FOR MULTIPLE TENDONS AND PATHOLOGIES.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $99.2k | 9/11/25 |