The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $644,152 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the University of North Carolina at Chapel Hill. The grant, effective from January 20, 2025 through December 31, 2029, aims to identify the mechanistic pathway linking aberrant limb-level loading during walking to the development and progression of knee osteoarthritis. The research will use in...
This federal Project Grant award of $678,213 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA Program 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research aims to evaluate the impact of over-constraint of the patella following medial patellofemoral ligament (MPFL) reconstruction surgery as a contributing factor to progressive cartilage degradation. The key objectives are to: 1) characterize cartilage degradation in 50 patients at least 5...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,476,001.00 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the systemic origins of osteoarthritis (OA). The key objective is to define how adipose (fat) tissue communicates with joint tissues to drive OA pathogenesis, with a focus on three potential interorgan crosstalk mechanisms: signaling...
This $456,808 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting the development of innovative mass spectrometry imaging (MSI) technologies to spatially visualize proteins and glycans in musculoskeletal tissues. The primary awardee, the Buck Institute for Research on Aging, is collaborating with researchers at the University of...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $196,460 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the University of Pittsburgh. The purpose of this 30-month grant, with a start date of January 30, 2025, is to develop and utilize a novel microphysiological system to study neuro-immune interactions that contribute to osteoarthritis (OA) pain. The research aims to: 1) understand how inflammatory molecules from...
The University of Arizona was awarded a $348,680 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The goal of this 2-year research project is to develop computational tools to accurately predict and interpret different knee pain spatial patterns in patients with osteoarthritis based on magnetic resonance imaging (MRI) data. The project aims to adapt a deep...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $174,689 to The General Hospital Corporation (doing business as Massachusetts General Hospital) for a 5-year research project. The project aims to investigate the relationship between structural damage biomarkers detected through MRI and CT imaging, and different pain phenotypes...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), aims to investigate the therapeutic role of the NFAT1 transcription factor in the treatment of osteoarthritis (OA). The $350,000 award, spanning from August 1, 2024 to July 31, 2029, will support two specific aims: 1) Investigating the therapeutic potential of AAV-NFAT1 (adeno-associated virus delivered NFAT1 transgene) in knee OA...
This three-year, $906,000 project grant from the National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases will fund research into obesity-promoting protein malonylation and its role in chondrocyte metabolic dysfunction and osteoarthritis development. Specifically, the grantee - Ohio University - will investigate how obesity accelerates osteoarthritis through "carbon stress," which causes metabolic byproducts to accumulate in cartilage...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $393,883 to Wake Forest University to conduct research on muscle power as a predictor of knee osteoarthritis in at-risk females. The primary aim is to determine if baseline levels of maximal concentric isotonic knee extensor muscle power can predict the incidence of structural...