Project Grant R56AR079647

Award Date 9/22/21
Completion Date 3/14/22
Dollars Obligated $1M
Federal Grant Program
93.846
Assistance Type
Project Grant
Place of Performance
California, USA
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The research will conduct a longitudinal cohort study of 100 individuals with isolated patellofemoral joint osteoarthritis followed over two time points. Simultaneous positron emission tomography-magnetic resonance imaging and gait biomechanics will be collected for all subjects at baseline and two-year follow-up. The research aims to identify cross-sectional and longitudinal local patterns of cartilage and bone interactions unique to patellofemoral joint osteoarthritis, and determine the mediating effects of gait biomechanics and bone morphology on disease progression. Findings could provide insight into patellofemoral joint osteoarthritis progression and individual responses to the disease.

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