Project Grant 2207577
- This National Science Foundation (NSF) Engineering Research Initiation (ERI) grant, award number 2347433, provides $200,000 in funding to Lafayette College to conduct fundamental research on the mechanical properties of ligaments and tendons. The goal is to better understand how these musculoskeletal tissues deform and fail by examining the mechanical behavior of the interfascicular matrix and fascicles that make up the tissue structure. The research team will use stereo digital image...
- The Regents of the University of Idaho received a three-year, $231,873 Project Grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation to understand regulators of collagen crosslinking enzymes for tendon formation. Funded under the NSF's Engineering program (CFDA 47.041), the research aims to define the mechanisms that control collagen crosslinking enzyme production by tendon and stem cells. Investigators will evaluate adult stem cells and tendon...
- The University of Connecticut received a $266,000 Project Grant award from the National Science Foundation under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084) to develop a delivery technology for large messenger RNA (mRNA) applications in cartilage and joint tissues. The university will introduce an innovative platform using DNA-inspired Janus base nanomaterials to help large mRNA enter tissues for biomedical uses from therapeutics to research reagents. Postdoctoral...
- This $500,000 project grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation supports research titled "GOALI/COLLABORATIVE RESEARCH: INSTABILITIES AND LOCAL STRAINS IN ENGINEERED CARTILAGE SCAFFOLD" being conducted at Cornell University from January 1, 2022 to December 31, 2024. The research aims to improve understanding of instabilities and local strains in engineered cartilage scaffolds, with the goal of enabling innovation in cartilage...
- This $300,000 project grant from the National Science Foundation will fund research at Cornell University from October 1, 2022 to September 30, 2025. The award is provided through NSF's Engineering Biology and Health Cluster within the Directorate for Engineering, Biological Sciences and Biotechnology, under the CFDA program for Engineering. Specifically, researchers at Cornell University and Washington State University will work to develop new tissue engineering strategies for cartilage repair....
- This National Science Foundation Project Grant of $523,303 supports research at the University of California, Merced from June 2023 through May 2028 under the Engineering program (CFDA 47.041). The award will fund investigation into the role of fibronectin in mediating the adsorption and retention of synovial fluid components to regulate joint boundary lubrication and wear protection. Specifically, the university researchers will develop articular cartilage surface models, quantify synovial...
- The National Science Foundation awarded Cornell University a $663,834 project grant under the Engineering program (CFDA 47.041) for a three-year investigation of fatigue-induced damage progression in tendon from February 1, 2021 to January 31, 2024. The grant will support Cornell's Office of Sponsored Programs in conducting a multiscale study of how fatigue damage accumulates and spreads within tendons over time at micro and macro levels. The Engineering program aims to improve quality of life...
- This $325,044 federal Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research to develop a new "aerodynamic fiber deposition" technology to manufacture biomimetic soft fiber-reinforced composites with spatially varying fiber arrangements. The research aims to enable the production of high-throughput, highly controlled nano/microfiber patterns that mimic the complex fiber structures found in biological tissues like skin, muscle, and...
- This Project Grant awarded by the National Science Foundation (NSF) under the Engineering program (CFDA 47.041) supports research to understand how human bone tissue dynamically adapts at the nanoscale level under various loading conditions. The $719,538 award to the Trustees of the University of Pennsylvania, made on May 1, 2024, will investigate the real-time rearrangement and deformation of the nanoscale components of healthy and osteoporotic bone tissue when subjected to cyclic loading....
- The University of North Texas received a $101,896 project grant award from the National Science Foundation Division of Materials Research under the Mathematical and Physical Sciences program (CFDA 47.049). The award will fund research from June 1, 2023 through May 31, 2024 to study the combined tribological and bactericidal effects of bioinjectable nanodiamonds on biological joints. Specifically, the researchers will examine how functionalized diamond nanoparticles interact with joint cells...
The National Science Foundation awarded a $750,000 Project Grant to Rutgers, The State University under the Engineering program (CFDA 47.041) from September 1, 2022 to August 31, 2025. The grant funds research to develop an injectable nanoparticle therapy to restore strength and length to damaged tendons and ligaments. Specifically, the university will investigate combining a thermosensitive polymer and crosslinking agent to stabilize joints by quickly strengthening and returning tissues like tendons and ligaments to their original condition after injuries. Researchers will create collagen-binding contractile nanoparticles and evaluate their composition, polymer concentration, and ability to bind collagen fibers. They will also study the crosslinking agent's release and effects on cell behavior and tissue strength. The university will then evaluate the nanoparticles' contractile and strength-enhancing effects in vivo by injecting them into an animal model of damaged tendons. If successful, the innovative therapy could benefit millions by improving wound healing and rapidly stabilizing injured joints.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $375.0k | 6/16/22 |