Project Grant K99AG097920
- Federal Grant Award Summary Brigham & Women's Hospital received a $3.69 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on September 15, 2025, with a completion date of September 14, 2029. The award funds development of specialized large language models (LLMs) designed to extract Alzheimer's disease and related dementias (ADRD)-relevant clinical phenotypes from electronic health records (EHRs). The project addresses a critical...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $335,880 Project Grant to Boston Children's Hospital on August 15, 2025, under the Aging Research program (CFDA 93.866) to conduct basic neuroscience research aimed at elucidating the molecular mechanisms underlying cognitive resilience to Alzheimer's Disease (AD). The research will extend through May 31, 2030, and focuses on understanding how 10-15% of individuals maintain normal cognition despite high levels of AD...
- Federal Project Grant Award Summary Massachusetts General Hospital's Research Management Division received a $269,452 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 18, 2026, with an ultimate completion date of November 30, 2028. The award funds a research project titled "Deciphering Proteomic Aging: From Causal Mechanisms to Frailty Prediction," which will integrate large-scale genetic, multi-omic, and clinical...
- Federal Project Grant Summary The Broad Institute of MIT and Harvard received a $1.22 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 1, 2025, and extending through May 31, 2030. The grant funds research into genetic dissection of mitonuclear interactions in aging and neurodegenerative disease, with particular focus on understanding how interactions between mitochondrial DNA (mtDNA) and nuclear genes contribute to...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $157,760 Project Grant to The General Hospital Corporation (Massachusetts General Hospital) on August 20, 2026, under the Aging Research program (CFDA 93.866) to support investigator-initiated biomedical research. The award funds a one-year research project through August 19, 2027, examining a novel mechanism of autophagic degradation in cellular senescence. The research investigates how ATG8 family proteins facilitate...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Boston University Medical Campus a $1.224 million Project Grant under the Aging Research program (CFDA 93.866) effective August 1, 2025 through April 30, 2030. The award supports multiscale modeling and empirical studies investigating the mechanisms linking normal and pathological brain aging to cognitive decline. The research focuses on progressive myelin dystrophy, synaptic loss, and neuronal hyperexcitability in the...
- Federal Grant Award Summary The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), awarded a $3.28 million Project Grant to Harvard T.H. Chan School of Public Health on September 15, 2025, with completion targeted for August 31, 2029. This research initiative addresses the interplay between herpesvirus infection, immune responses, apolipoprotein E (APOE) genotype, and tau-pathology development in Alzheimer's disease (AD). The primary deliverable is scientific...
- Federal Grant Award Summary Brigham & Women's Hospital Inc. received a $492,250 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 15, 2025, with completion targeted for August 31, 2027. The research project investigates whether regulatory T cells (Tregs) are dysfunctional in Alzheimer's disease and, if so, whether restoring Treg functionality could mitigate disease progression. The project builds upon existing evidence...
- Federal Project Grant Award Summary Beth Israel Deaconess Medical Center, Inc. (BIDMC) received a $761,496 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded June 15, 2026, with an ultimate completion date of February 28, 2031. The project, titled "From Cells to Society: Using Epigenetics to Understand Brain Vulnerability to Delirium and Cognitive Decline," delivers research services aimed at identifying epigenetic...
- Federal Project Grant Award Summary Emory University received a $3.25 million Project Grant from the National Institute on Aging (CFDA 93.866: Aging Research) effective September 1, 2025, through August 31, 2029. This award supports biomedical research investigating the role of indole and related metabolites produced by commensal microbiota in promoting mobility and healthspan during aging. The research project focuses on understanding how indole compounds, secreted by beneficial bacteria,...
Brigham and Women's Hospital Inc. received a $135,540 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective July 1, 2026, through June 30, 2028. This K99/R00 award funds a multi-omics research initiative investigating microbial aging dynamics and their relationship to cognitive health and Alzheimer's disease and related dementias (AD/ADRD). The project employs longitudinal analysis and machine learning methodologies to examine interactions between genetic predispositions (including APOE4 and polygenic risk scores), gut microbiome composition and function, and cognitive outcomes across multiple prospective cohorts. The research deliverables include: (1) analysis of interrelationships between genetic risk factors for AD/ADRD and microbial taxonomic and functional profiles to test whether genetic predispositions modulate microbial contributions to cognitive decline; and (2) development of microbiome-based aging clocks using machine learning algorithms validated through an international microbiome consortium. These outputs are intended to identify novel, modifiable risk factors and therapeutic targets for early cognitive decline by elucidating the gut-brain axis mechanisms through which the microbiome influences immune responses, metabolic processes, and neurotransmitter synthesis in genetically susceptible populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $135.5k | 7/1/26 |