Project Grant RF1AG078244

Award Date 9/1/23
Completion Date 8/31/26
Dollars Obligated $1.7M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
New York, NY 10065, USA
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This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
The Project Grant award for "NEURODEGENERATIVE REPROGRAMING OF MICROGLIA IN ALZHEIMER'S DISEASE" was provided by the National Institute on Aging (CFDA 93.866 Aging Research) in the amount of $442,357.00. The grant, awarded to the Research Foundation of the City University of New York (RFCUNY), aims to elucidate the molecular mechanisms underlying a specific subset of stressed "dark" microglia and their neurodegenerative impact in Alzheimer's disease (AD) models. The...
This National Institutes of Health (NIH) National Institute on Aging (CFDA 93.866 Aging Research) Project Grant award of $614,424 to the University of Washington is for a research project titled "Illuminating Early Microglial Dysfunction in Alzheimer's Disease Through Integration of Explainable AI and iPSC Models." The project aims to use novel AI techniques and human-derived induced pluripotent stem cell (iPSC) models to better define how microglia, the brain's immune cells,...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
The National Institute on Aging (NIA) awarded a $613,571 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Chicago to develop in vivo production of chimeric antigen receptor (CAR)-modified microglia for treating Alzheimer's disease. The project aims to use blood-brain barrier crossing lipid nanoparticles to deliver mRNA encoding anti-amyloid-beta CAR constructs and interleukin-10 (IL-10) to induce an anti-inflammatory microglial response and...
The National Institute on Aging awarded a $871,093 Project Grant (CFDA 93.866 - Aging Research) to the Sloan-Kettering Institute for Cancer Research in New York, NY. The 5-year grant from January 1, 2025 to December 31, 2029 will fund research to elucidate the mechanisms underlying the regulation of the transcription factor EB (TFEB) and the autophagy-lysosomal pathway, and investigate their therapeutic potential as treatments for Alzheimer's disease. The research will utilize...
The National Institute on Aging (NIA) awarded a $2,027,220 Project Grant under the Aging Research program (CFDA 93.866) to the Oklahoma Medical Research Foundation (OMRF) to investigate the role of major histocompatibility complex I (MHC-I) in regulating microglial function during aging and Alzheimer's disease. The 3-year project aims to: 1) determine if MHC-I expression regulates microglial reactivity and phagocytic phenotypes with aging, 2) assess if MHC-I suppression impacts prodromal...
The National Institute on Aging (NIA) awarded a $1,994,202 Project Grant under CFDA 93.866 - Aging Research to Mayo Clinic Jacksonville (A Nonprofit Corporation) to research a new microglial therapy candidate for Alzheimer's disease (AD) that could prevent cognitive decline. The grant aims to target the tumor susceptibility gene 101 (TSG101) in microglia to manipulate extracellular vesicle secretion and mitigate tau pathology development. The research will be conducted in three phases: targeting...
This $3.6 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at the Icahn School of Medicine at Mount Sinai directed at understanding the role of glial cell interactions surrounding amyloid plaques in the progression of Alzheimer's disease. As part of the Aging Research program (CFDA 93.866), the three-year award will support investigation of how deletion of the Plexin-B1 gene impacts glial network formation and the...

The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $1,684,689 project grant to Weill Medical College of Cornell University to study the role of microglial lysosomes in the degradation of amyloid-beta, a key pathological feature of Alzheimer's disease. The 3-year project aims to characterize the process of "digestive exophagy" used by microglia to limit the expansion of amyloid-beta plaques, as well as explore the effects of genetic mutations linked to Alzheimer's on this process. Additionally, the research will examine whether the secretion of lysosomal contents during digestive exophagy contributes to the spread of tau and amyloid-beta fibrils. The project leverages primary mouse microglia and human iPSC-derived microglial cells to advance the understanding of microglial function in Alzheimer's disease pathogenesis, with the goal of informing future therapeutic strategies.

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