Project Grant K23MH139900
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a $744,121 Project Grant (CFDA 93.242: Mental Health Research Grants) effective July 14, 2025, through April 30, 2030, to develop Foundation Models (FMs) for human functional neuroimaging with applications to psychiatric disorders. The research initiative aims to create an integrated framework combining foundation models with explainable artificial intelligence (XAI)...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded Stanford University a $1.46 million Project Grant under the Mental Health Research Grants program (CFDA 93.242) to develop optimized methods for measuring brain excitability in depression. Initiated on May 1, 2025, with completion targeted for February 28, 2030, this research addresses critical limitations in Repetitive Transcranial Magnetic Stimulation (rTMS) treatment for depression, which currently exhibits...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a $1,066,793 Project Grant (CFDA 93.242 – Mental Health Research Grants) effective April 1, 2026, through January 31, 2028, to develop and validate a personalized Intermittent Theta-Burst Stimulation (ITBS) protocol for treatment-resistant depression (TRD). The research delivers neurophysiological biomarker development and clinical validation services through a two-phase study...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded Massachusetts General Hospital a $790,560 Project Grant under the Mental Health Research Grants program (CFDA 93.242) effective April 1, 2026 through March 31, 2030. The award funds development of advanced artificial intelligence models to predict differential antidepressant treatment responses by integrating electronic health record (EHR) data with genomic information. The research addresses critical...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded $818,253 to The Regents of the University of California, San Francisco under the Mental Health Research Grants program (CFDA 93.242) beginning July 1, 2025, and extending through April 30, 2030. This Project Grant supports a five-year research investigation examining neuromodulatory system abnormalities in late-life depression (LLD), with specific focus on the associations between structural and functional brain...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded University of Miami a $731,258 Project Grant, effective March 1, 2026, through November 30, 2030, under the Mental Health Research Grants program (CFDA 93.242). This research project aims to map neural dynamics associated with Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) by utilizing high-stakes, real-world events as stimuli. The study will employ functional magnetic resonance imaging...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded $394,200 to the Research Foundation For Mental Hygiene, Inc. (through its New York State Psychiatric Institute division) under the Mental Health Research Grants program (CFDA 93.242) on August 1, 2025, for a five-year project period extending through July 31, 2030. This Project Grant funds a clinical research study examining the role of the anterior hippocampus in major depressive disorder (MDD) pathogenesis....
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a Project Grant totaling $160,272 under the Mental Health Research Grants program (CFDA 93.242) for the period of June 1, 2025, through May 31, 2027. This research project, titled "Theta Burst Modulation of Hippocampal-Cortical Rhythms in Schizophrenia," investigates whether connectivity-guided theta burst stimulation (TBS) can alter hippocampal neural activity and...
- Federal Grant Award Summary On September 12, 2025, the National Institute of Mental Health (NIMH) awarded Miresource, Inc. a Project Grant of $627,600 under the Mental Health Research Grants program (CFDA 93.242) to develop an integrated mental health monitoring and personalized recommendation system. In partnership with the Child Mind Institute (CMI), a nonprofit research organization, Miresource will integrate existing software solutions—including CMI's MindLogger mobile platform, MOSAIC...
- Federal Grant Award Summary The Laureate Institute for Brain Research, Inc. received a $514,178 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective July 1, 2025, through April 30, 2030. The award funds a five-year research initiative investigating the mechanistic relationships between brain circuits and negative valence system behaviors in treatment-resistant depression (TRD) using low-intensity...
The National Institute of Mental Health (NIMH) awarded The Leland Stanford Junior University a $192,192 Project Grant (CFDA 93.242 – Mental Health Research Grants) on April 15, 2026, for an artificial intelligence foundation model project addressing major depressive disorder (MDD) through functional neuroimaging analysis. The project, which extends through March 31, 2031, will develop and validate an AI-based tool leveraging transformer architecture and foundation models to predict antidepressant treatment response, stratify patients for personalized treatment, and discover distinct MDD biotypes. The research adapts pretrained models originally developed on large non-clinical datasets (UK Biobank and Human Connectome Project) to analyze functional magnetic resonance imaging (fMRI) time-series data from individuals with MDD. The grant deliverables encompass three primary aims: fine-tuning the pretrained model using pooled fMRI data to decode depression severity and identify MDD biotypes; adapting the model with longitudinal treatment data to predict antidepressant response and map neural circuits associated with treatment outcomes; and prospectively validating the MRI-based treatment prediction models in a pilot clinical trial. These outputs will generate computational tools, predictive algorithms, and mechanistic insights intended to advance understanding of MDD heterogeneity and enable evidence-based individualized treatment approaches, directly supporting NIMH's mission to transform mental illness treatment through basic and clinical research.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $192.2k | 4/17/26 |