This $1,470,094 project grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) will fund research by New York University School of Medicine to optimize pre-implantation kidney transplant biopsy interpretation using artificial intelligence (AI) assistance. The key products and services to be delivered under this 5-year project include: Developing a comprehensive unbiased atlas of histopathology in pre-implantation deceased donor kidney biopsies using...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $200,000.00 to New York University School of Medicine to conduct a case-cohort study investigating novel determinants of risk for living kidney donors. The key objectives are to: 1) use qualitative research to inform recruitment strategies and messaging to maximize participation of...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $192,215 to The Regents of the University of California, San Francisco (UCSF) to assess patient-centric factors and enhance risk communication to improve treatment persistence for sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists...
This $830,500 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research by Georgetown University to investigate the role of glycosphingolipids in kidney disease associated with diabetes and obesity. The research aims to determine if inhibiting glucosylceramide synthesis can prevent kidney disease progression, improve mitochondrial function, and reduce...
The University of Illinois received a $1,695,959 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) to perform kidney functional magnetic resonance imaging (fMRI) on 420 participants with chronic kidney disease (CKD) recruited from 7 sites. The goal is to test the associations of kidney fMRI biomarkers with chronic histopathologic lesions and changes in kidney function over time. The...
This Project Grant award of $3,740,270, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports the development and evaluation of a subnormothermic (room temperature) oxygenated perfusion platform for extended preservation of high-risk kidney grafts. The awardee, Biomedinnovations, Inc. (BMI), is collaborating with investigators at the Duke Ex Vivo Organ Lab...
This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a systems biology research project conducted by the Regents of the University of Michigan. The key objectives are to: 1) Validate predicted transcription factor binding motifs related to the hypoxia-inducible factor 1-alpha (HIF1A) in areas of open chromatin using multiomics data, and 2)...
The federal Project Grant award R01DK140070, in the amount of $700,619, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research (CFDA 93.847) program. The goal of this 4-year award is to study and control rhythmic nephron induction for kidney replacement tissues. The research aims to gain temporal control over rhythmic nephron formation in human induced pluripotent stem cell-derived kidney...
This $223,176 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the impact of APOL1 copy number variations (CNVs) on kidney disease susceptibility in African Americans. The award recipient, Beth Israel Deaconess Medical Center (BIDMC), will develop computational approaches to characterize the risk variant architecture of APOL1 CNVs and determine the...
This federal Project Grant award of $105,398.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project aims to assess the persistent effects of dietary protein restriction on protein motivation and underlying physiology in animals. Specifically, the research will examine measures of protein preference, economic "demand", FGF21 production, and...