This federal Project Grant award of $671,986 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to strengthen the evidence-base for medication prescribing in older adults with chronic kidney disease (CKD). The primary objectives are to: 1) Evaluate the effectiveness of renoprotective therapies, such as angiotensin converting enzyme inhibitors (ACEIs) and sodium-glucose...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,439,769 project grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Southern California. This 5-year study, titled "PFAS Exposure and Diabetic Kidney Disease in Youth with Type 2 Diabetes: A Multi-Omic Approach for Prevention and Treatment," aims to investigate the link between exposure to per- and polyfluoroalkyl substances...
This $166,953 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a pilot, pragmatic, cluster-randomized clinical trial to investigate increasing the use of SGLT2 inhibitors after acute kidney injury (AKI) in patients with type 2 diabetes. The project aims to assess the feasibility of this intervention, identify barriers to prescribing and patient adherence through...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to demonstrate the clinical utility of patient-reported outcome measures (PROMs) in the care of individuals with advanced chronic kidney disease (CKD). The $199,130 award will fund three key activities: 1) Developing and validating risk stratification models that incorporate PROM data to...
This Project Grant award, totaling $193,652, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will support a 5-year research project led by Dr. Carrie Thiessen at the University of Wisconsin-Madison to assess the impact of cognitive biases on patient and provider willingness to accept imperfect kidneys for transplantation. The research aims to...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $176,244 to The Regents of the University of California, San Francisco (UCSF) to support a 5-year research and training plan. The goal is to prepare Dr. Gabriel Loeb to lead an independent academic research program focused on understanding the mechanisms underlying ciliary...
This Project Grant award of $1,188,167 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847, the Diabetes, Digestive, and Kidney Diseases Extramural Research program, supports research to develop inhibitors of the sphingosine 1-phosphate (S1P) signaling pathway as potential therapies for chronic kidney disease (CKD). The primary awardee, Virginia Polytechnic Institute & State University (Virginia Tech), will work to improve the oral...
This federal Project Grant award of $319,990 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a 12-week randomized controlled trial to compare medical nutrition therapy personalized by continuous glucose monitoring (CGM) feedback to three control interventions in 72 adult participants with type 2 diabetes mellitus. The primary objective is to determine if CGM-informed personalized...
This $531,999 federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847), will support research at Washington University on the role of alternative splicing in the progression of diabetic kidney disease (DKD). The research aims to: 1) Define and validate the spectrum of alternative splicing in DKD and the impact of sodium-glucose cotransporter 2 inhibitor (SGLT2i) treatment using long-read RNA sequencing; 2) Test the hypothesis...
This $830,500 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research by Georgetown University to investigate the role of glycosphingolipids in kidney disease associated with diabetes and obesity. The research aims to determine if inhibiting glucosylceramide synthesis can prevent kidney disease progression, improve mitochondrial function, and reduce...