Project Grant R01DK139321

This federal Project Grant award of $1,695,959.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The primary goal of the project is to evaluate the use of gadolinium-free kidney functional magnetic resonance imaging (fMRI) to identify high-risk phenotypes of chronic kidney disease (CKD). The project will analyze fMRI data from 420 participants with CKD recruited across 7 sites, and conduct 2-year follow-up fMRI scans on a subset of 210 participants. The researchers will test the associations between fMRI biomarkers and chronic histopathologic lesions, as well as changes in kidney function over time. The project will also extract fMRI radiomic features to identify potential imaging sub-phenotypes of CKD. Relevant sub-awards will support the coordination of fMRI scans, data analyses, and interpretation of results across the participating research sites, which include institutions such as the Icahn School of Medicine at Mount Sinai, University of Texas Southwestern Medical Center, and University of North Carolina at Chapel Hill.