This federal Project Grant award of $344,632 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research to evaluate the impact of recent changes to the kidney allocation system in the United States. The research aims to: (1) assess whether the supply of organs is equitably distributed among U.S. transplant centers under the new 250-nautical-mile kidney...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $147,656 Project Grant to Beth Israel Deaconess Medical Center, Inc. (Bidmc) to study the impact of APOL1 copy number variations on kidney disease susceptibility in African Americans. The 2.5-year grant, which began on January 11, 2025, will fund research to characterize the risk variant architecture of APOL1 copy number variations and determine the functional consequences of harboring these variations. The...
The federal Project Grant award R01DK140129, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to optimize the allocation of kidneys from deceased African American donors with APOL1 high-risk genotypes. The primary goal is to identify clinically actionable approaches to determine which of these kidneys are truly "high risk" for...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $133,500 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Boston Medical Center Corporation (BMC) with a start date of September 1, 2024 and end date of August 31, 2026. The grant will fund research on the relationship between APOL1 genotypes and biomarkers of immune activation and tubular injury in the context of chronic kidney disease (CKD) in sub-Saharan...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $731,071 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Johns Hopkins University. The grant aims to address barriers that prevent equitable provision of guideline-recommended diabetes care in the United States. The study will leverage real-world datasets on persons with diabetes to describe disparities in care receipt, examine disparities in...
This $166,643 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports the development of robust phenotyping pipelines for early detection of collagen type IV-associated nephropathy (COL4A-AN) using electronic health records (EHR) data. The primary goal is to establish scalable phenotyping methods that leverage natural language processing (NLP) and...
This is a $400,000 project grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The goal of the project is to understand the earliest events in podocyte injury caused by mutations in collagen IV, which can lead to chronic kidney disease and end-stage renal failure. The research will use transcriptomic data from mouse models and human patient samples to identify...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to use a systems biology approach to identify gene regulatory networks related to hypoxia inducible factor-1a (HIF1a) in the kidney cortex and medulla. The $117,000 award, which runs from January 1, 2025 to December 31, 2026, will focus on validating predicted transcription factor...
This Project Grant award in the amount of $2,202,378.00 was awarded on September 20, 2024 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research to investigate the protective role of the transcription factor KLF2 in diabetic kidney disease (DKD) and its potential as a drug target. The key objectives are to determine how KLF2 is regulated in diabetic...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to develop an AI-assisted system for interpreting kidney biopsy images to reduce inappropriate organ discards. The $1,470,094 award to New York University School of Medicine aims to: (1) construct a comprehensive atlas of kidney biopsy histopathology using...