This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), totaling $192,780, will fund research to evaluate the impact of discontinuing medications for opioid use disorder (MOUD) after surgery. The research aims to identify risk factors for MOUD discontinuation and estimate the association between MOUD discontinuation and adverse postoperative outcomes. The study will leverage three large, nationally...
This $701,959 Project Grant awarded by the National Institute on Drug Abuse (CFDA 93.279 Drug Use and Addiction Research Programs) aims to improve perioperative care for patients with opioid tolerance undergoing common surgical procedures. The key objectives are to: Capture patient-reported opioid use and pain outcomes among opioid-tolerant individuals after surgery and develop guidelines for appropriate opioid prescribing in this population. Conduct qualitative interviews to inform the...
This federal Project Grant award from the National Institutes of Health (CFDA 93.279 - Drug Abuse and Addiction Research Programs) provides $1,105,489 to The Leland Stanford Junior University (Stanford University) to fund research aimed at reducing the risk of persistent postoperative opioid use and opioid use disorder among older adults undergoing inpatient surgery. The key products and services to be delivered under this 2-year grant include: Augmenting an existing dataset that links...
This Project Grant award, with a total funding amount of $379,792, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award aims to develop and pilot test the "Patient Reported Outcome Measures to Individualize Treatment and Improve Retention" (RETAIN) program intervention package. This program will capture patient-reported outcome measures (PROMs) in Federally-Qualified Health Center (FQHC)-based opioid use...
This $779,969 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to improve perioperative care for patients with opioid use disorder. The grant will fund a 5-year study to prospectively capture patient-reported pain and opioid use among individuals with opioid use disorder undergoing common surgical procedures, and develop a clinical care pathway to optimize perioperative outcomes across a network of...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $197,748 to The Regents of the University of California, San Francisco to develop and pilot an enhanced low-dose buprenorphine initiation (LDI) program. The goal is to improve treatment outcomes for individuals with opioid use disorder, particularly those using fentanyl, by overcoming barriers to successful buprenorphine initiation and...
This $598,312 federal Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to integrate and assess the practicality of a closed-loop medication management system for opioid pain management in emergency department patients with extremity fractures. The key product being developed and evaluated is the ADDINEX system, which packages opioid medications in mechanical dispensers that restrict access to individual...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $238,500 to the University of Pittsburgh to conduct a randomized, blinded clinical trial evaluating a telemedicine-delivered digital cognitive behavioral intervention (DCBI) to reduce postoperative opioid use among patients undergoing total knee and hip arthroplasty. The research aims to quantify the opioid-sparing effects of the DCBI, evaluate its...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $208,575.00 to Dr. R. Kathryn McHugh at McLean Hospital to expand her mentorship of early-career investigators in patient-oriented research (POR) on substance use disorders. The award will enable Dr. McHugh to dedicate more time to mentoring current and new mentees, as well as broaden her own POR program. This includes extending existing...
The National Institute on Drug Abuse (NIDA) awarded a $267,000 Project Grant (CFDA 93.279 - Drug Use and Addiction Research Programs) to The Children's Hospital Corporation, doing business as Boston Children's Hospital, to develop depot formulations for on-demand, tamper- and diversion-proof delivery of opioids. The project aims to create injectable, polymer-based depot formulations that covalently bond opioids using photolabile linkers. This approach would prevent tampering and diversion, while...
BEHAVIOR CHANGE COMPONENTS TO ENHANCE OPIOID DISPOSAL AFTER SURGERY - PROJECT SUMMARY/ABSTRACT THIS IS AN APPLICATION FOR A K23 AWARD FOR DR. LYEN HUANG, A SURGEON AND HEALTH SERVICES RESEARCHER AT THE UNIVERSITY OF UTAH. DR. HUANG IS ESTABLISHING HIMSELF AS A YOUNG INVESTIGATOR IN PERIOPERATIVE PATIENT SAFETY. HIS CURRENT RESEARCH FOCUSES ON REDUCING OUR HEALTHCARE SYSTEM'S CONTRIBUTIONS TO THE OPIOID CRISIS. THIS K23 WILL ENABLE DR. HUANG TO ACCOMPLISH THE FOLLOWING GOALS: (1) DEVELOP EXPERTISE IN USING PATIENT-FACING BEHAVIOR CHANGE COMPONENTS FOR PROMOTING HEALTHY BEHAVIORS, (2) DEVELOP EXPERTISE IN IMPLEMENTATION SCIENCE TO CLOSE THE GAP MORE RAPIDLY BETWEEN RESEARCH AND HEALTH SYSTEM INTERVENTIONS, (3) GAIN LEADERSHIP AND MANAGEMENT SKILLS TO SUPPORT TRANSDISCIPLINARY, MULTI-INSTITUTIONAL RESEARCH AND TRIALS, AND (4) TRANSITION TO AN INDEPENDENT RESEARCH CAREER. TO ACHIEVE THESE GOALS, DR. HUANG HAS ASSEMBLED A MENTORING TEAM COMPRISED OF A PRIMARY MENTOR, DR. KIMBERLY KAPHINGST, A LEADING RESEARCHER IN HEALTH LITERACY, PATIENT-PROVIDER COMMUNICATION, AND BEHAVIOR CHANGE INTERVENTIONS; AND A CO-MENTOR, DR. ALEX SOX-HARRIS, A NATIONAL EXPERT IN SURGICAL AND ADDICTION HEALTH SERVICES RESEARCH AND IMPLEMENTATION SCIENCE. DR. HUANG ALSO HAS FIVE ADVISORS WITH EXPERTISE IN SURGICAL LEADERSHIP; PERIOPERATIVE, ADDICTION MEDICINE, AND CANCER HEALTH EQUITY INTERVENTIONS; PRAGMATIC TRIALS IN RURAL COMMUNITIES; CLINICAL TRIALS; BIOSTATISTICS; AND SURVEY METHODOLOGY. ALTHOUGH 42 MILLION PATIENTS ARE PRESCRIBED OPIOIDS AFTER SURGERY EACH YEAR, WE CURRENTLY LACK AN EFFECTIVE AND SCALABLE INTERVENTION FOR MOTIVATING PATIENTS TO DISPOSE OF LEFTOVER OPIOIDS. FEW PATIENTS DISPOSE OF THEIR LEFTOVER OPIOIDS, AND EXISTING INTERVENTIONS HAVE SHOWN MIXED REAL-WORLD RESULTS. INSTEAD, PATIENTS INSECURELY STORE, MISUSE, OR SHARE OPIOIDS PUTTING THEMSELVES, FAMILIES, AND COMMUNITIES AT RISK. THE OBJECTIVE OF DR. HUANG'S RESEARCH IS TO DEVELOP AND IMPLEMENT A THEORY- AND EVIDENCE-BASED OPIOID DISPOSAL INTERVENTION. DR. HUANG WILL (AIM 1) EVALUATE THE FEASIBILITY AND ACCEPTABILITY OF BEHAVIOR CHANGE COMPONENTS TO ENHANCE THE UNIVERSITY OF UTAH'S CURRENT DISPOSAL INTERVENTION; (AIM 2) PREPARE FOR IMPLEMENTATION AND EVALUATION IN DIFFERENT POPULATIONS AND SETTINGS; AND (AIM 3) TEST AND REFINE THE ENHANCED OPIOID DISPOSAL INTERVENTION. THE EXPECTED OUTCOME WILL PROVIDE THE EVIDENCE FOR MULTI-INSTITUTIONAL TRIALS OF AN INTERVENTION TO PROMOTE SAFE OPIOID DISPOSAL ACROSS THE COUNTRY. THE PROPOSED RESEARCH IS INNOVATIVE IN THE APPLICATION OF BEHAVIOR CHANGE AND IMPLEMENTATION THEORIES TO THE PREVENTION OF IATROGENIC CONTRIBUTIONS TO THE OPIOID CRISIS AND THE USE OF AN ONGOING SYSTEM-WIDE OPIOID DISPOSAL INTERVENTION ALLOWING FOR RAPID, ITERATIVE REFINEMENT AND EVALUATION.