This $2,267,819 Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Abuse and Addiction Research Programs) will fund research by the University of Washington to characterize extracellular vesicle (EV) profiles in healthy pregnancies and those complicated by opioid use disorder. The goal is to identify biomarkers in placental EVs and fetal brain/central nervous system EVs that could predict an infant's risk of developing neonatal opioid withdrawal syndrome (NOWS) and...
The National Institute on Drug Abuse (NIDA) awarded The Washington University a 3-year, $2,337,729 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to study the impact of prenatal opioid exposure on placental and fetal brain development. The project, titled "The Opioid in Pregnancy: Imaging of Oxygenation, Inflammation, and Development in Brain & Placenta" (OPIOID BPP), aims to define the longitudinal effects of prenatal opioid exposure on...
The federal Project Grant award R01DA062152 was issued by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). This $1,499,606 award, effective September 30, 2024 through July 31, 2029, will fund research by Dartmouth-Hitchcock Clinic to characterize the health outcomes of children born to individuals with opioid use disorder (OUD) from birth to 5 years of age. The project aims to identify disparities in outcomes based on race,...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the federal Drug Use and Addiction Research Programs (CFDA 93.279) provides $945,397 to the Magee-Womens Research Institute and Foundation to adapt and evaluate a Collaborative Care Model (CCM) for pregnant persons with opioid use disorder (OUD) in low-resource obstetric settings. The award has two main goals: 1) to adapt an existing CCM for rural and low-resource obstetric settings, and 2) to evaluate the effects of...
The National Institute on Drug Abuse (NIDA) awarded Magee-Womens Research Institute and Foundation a $3,092,159 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to conduct a multimodal analysis of gestational health and placental injury in opioid-affected pregnancies. The goal is to investigate the direct impact of illicit and prescription opioids on placental development, differentiation, and function, focusing on the critical syncytiotrophoblast and...
This Project Grant award of $1,871,814 from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will establish a Patient Engagement Resource Center (PERC) to support parents with substance use disorders (SUD). The key objectives are to: 1) Build a Lived Expertise Advisory Panel (LEAP) of 18 parents with SUD to guide the research and decision-making; 2a) Conduct a mixed-methods research project with 190 quantitative and 40...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $368,315 to the Georgia State University Research Foundation Inc. to design and test a novel rat model of the neonatal intensive care unit (NICU) experience. The project aims to delineate the mechanisms by which early adverse experiences in the NICU, including pain, resource scarcity, and separation from caregivers, can increase the risk of...
The National Institute on Drug Abuse (NIDA) awarded a $3,503,736 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Seattle Children's Hospital (doing business as Seattle Children's Research Institute) to develop and test a multilevel substance use disorder (SUD) and overdose prevention strategy for rural youth involved in the county legal system. The 2-year R61 phase will co-design the multilevel SUD/overdose prevention strategy and implementation plan with...
The National Institutes of Health (NIH) awarded Boston Medical Center Corporation a $2,573,346 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279). The 3-year grant, which commenced on September 1, 2023, will fund a prospective cohort study comparing 100 opioid-exposed pregnancies to 50 non-exposed controls. The study aims to: Compare serial microRNA (miRNA) signatures in opioid-exposed and control pregnancies using maternal plasma and placental tissue samples. The...
This Project Grant award of $3,011,183 from the National Institute on Drug Abuse (NIDA), under the Drug Abuse and Addiction Research Programs (CFDA 93.279), supports research to investigate the effects of maternal opioid use disorder (OUD) on the placenta-brain axis and associated neurocognitive outcomes in offspring. The University of Kentucky Research Foundation, the prime awardee, will utilize a systems biology approach to integrate phenotypic, functional, and genomic data from the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $180,059 to the Research Institute at Nationwide Children's Hospital (RINCH) to study the developmental outcomes of children with neonatal opioid withdrawal syndrome (NOWS). The key objectives are to: 1) engage a community advisory board to identify patient-centered outcomes and intervention approaches, 2) assess the independent and moderating effects of positive childhood experiences (PCEs) and adverse childhood experiences (ACEs) on neurodevelopmental outcomes in a prospective cohort of NOWS infants, and 3) examine the association between individual PCEs and components with neurodevelopmental outcomes in NOWS children. This award will support RINCH's research to better understand and promote optimal developmental trajectories for children affected by in-utero substance exposure, with the ultimate goal of developing future interventions. The award period is from August 1, 2024 to July 31, 2029.