Project Grant R01HD113143

Award Date 9/1/23
Completion Date 8/31/26
Dollars Obligated $2.6M
Funding Federal Agency
National Institute on Drug Abuse
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
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The National Institutes of Health (NIH) awarded Boston Medical Center Corporation a $2,573,346 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279). The 3-year grant, which commenced on September 1, 2023, will fund a prospective cohort study comparing 100 opioid-exposed pregnancies to 50 non-exposed controls. The study aims to:

  1. Compare serial microRNA (miRNA) signatures in opioid-exposed and control pregnancies using maternal plasma and placental tissue samples. The goal is to identify top miRNA associations with prenatal opioid exposure.

  2. Compare serial inflammatory cytokine levels in opioid-exposed and control pregnancies using maternal plasma, placental tissue, and cord blood samples. The objective is to identify top cytokine associations.

  3. Evaluate associations between the top miRNAs/cytokines identified in Aims 1-2 with placental health, infant neuroimaging, and 12-month neurodevelopmental outcomes in the opioid-exposed cohort.

Boston University Medical Campus is serving as a sub-grantee, overseeing the genetics analysis components and supervising a research data analyst.

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