The National Institute on Drug Abuse (NIDA) awarded The Washington University a 3-year, $2,337,729 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to study the impact of prenatal opioid exposure on placental and fetal brain development. The project, titled "The Opioid in Pregnancy: Imaging of Oxygenation, Inflammation, and Development in Brain & Placenta" (OPIOID BPP), aims to define the longitudinal effects of prenatal opioid exposure on...
The National Institute on Drug Abuse (NIDA) awarded Magee-Womens Research Institute and Foundation a $3,092,159 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to conduct a multimodal analysis of gestational health and placental injury in opioid-affected pregnancies. The goal is to investigate the direct impact of illicit and prescription opioids on placental development, differentiation, and function, focusing on the critical syncytiotrophoblast and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Federal Grant Program titled "Drug Use and Addiction Research Programs" (CFDA 93.279), provides $180,059 to the Research Institute at Nationwide Children's Hospital to conduct research aimed at optimizing developmental outcomes in early childhood after neonatal opioid withdrawal syndrome (NOWS). The key objectives of this 5-year research project are to: 1) engage community partners to identify...
The National Institutes of Health (NIH) awarded Boston Medical Center Corporation a $2,573,346 Project Grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279). The 3-year grant, which commenced on September 1, 2023, will fund a prospective cohort study comparing 100 opioid-exposed pregnancies to 50 non-exposed controls. The study aims to: Compare serial microRNA (miRNA) signatures in opioid-exposed and control pregnancies using maternal plasma and placental tissue samples. The...
This Project Grant award of $3,011,183 from the National Institute on Drug Abuse (NIDA), under the Drug Abuse and Addiction Research Programs (CFDA 93.279), supports research to investigate the effects of maternal opioid use disorder (OUD) on the placenta-brain axis and associated neurocognitive outcomes in offspring. The University of Kentucky Research Foundation, the prime awardee, will utilize a systems biology approach to integrate phenotypic, functional, and genomic data from the...
The federal Project Grant award of $314,225 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund research to explore the unique neurobehavioral effects of concurrent opioid and methamphetamine use disorders. The study aims to: 1) define the behavioral profile of dual opioid-methamphetamine use disorders in a rodent model, and 2) map neural activation patterns within the cortico-basal ganglia-thalamic circuit in response to...
This $519,501 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research into the role of the lateral hypothalamus (LHA) and its modulation of the dopamine system in mediating motivation for opioid reward. The research project aims to 1) determine the causal behavioral function of multiple LHA neuron subpopulations during motivation for opioids, and 2) characterize the relationship between bulk...
This $6,439,263 federal Project Grant awarded by the National Institute on Drug Abuse (CFDA 93.279 Drug Abuse and Addiction Research Programs) aims to determine the impact of maternal substance use on maternal immune activation, placental function, and offspring neurobehavioral development. The project will leverage the Healthy Brain and Child Development (HBCD) study to perform maternal immune profiling, placental and cord blood analysis, and novel neuroinflammation imaging on 400 pregnancies...
The Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to characterize health outcomes in children born to individuals with opioid use disorder (OUD) and identify protective health system factors. The award, totaling $1,499,606.00, was granted to the Dartmouth-Hitchcock Clinic and will run from September 30, 2024 to July 31, 2029. The key objectives are to: 1) Examine variation in the diagnosis of...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $284,040 to the Lieber Institute for Brain Development to conduct research on the molecular mechanisms underlying opioid addiction. The project aims to use integrated single-cell and spatial transcriptomic approaches to map gene expression changes in specific cell populations and projection neurons within the habenula, a key brain region...