Project Grant K23AG084850

Award Date 8/9/24
Completion Date 4/30/29
Dollars Obligated $369K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Nashville, TN 37203, USA
Similar Awards
This Project Grant awarded by the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research aims to comprehensively measure plasma levels of phosphorylated tau (p-tau217) and amyloid-beta (Aβ42/40) in Hispanic, African American, and non-Hispanic white populations participating in the Health and Aging Brain Study - Health Disparities (HABS-HD) study. The $1,128,979 award, effective September 1, 2024 through May 31, 2029, will enable researchers at the University of Southern...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to discover and characterize novel tau proteoforms in blood that can differentiate Alzheimer's disease (AD) and progressive supranuclear palsy (PSP) from healthy controls. The $3,687,575 award to the Trustees of Indiana University, Indianapolis, will leverage samples from completed clinical trials of tau immunotherapies to overcome sensitivity limitations and identify potential biomarkers for...
This $2,190,943 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research study conducted by the University of Alabama at Birmingham (UAB) to examine the relationship between tau protein deposition and functional brain network health in individuals at risk for Alzheimer's disease (AD). The key objectives of the study are to: 1) Use tau positron emission tomography (PET) and resting-state functional magnetic resonance imaging (fMRI) to...
This Project Grant award of $1,526,066 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the mechanisms by which the protein tau and mitochondrial dysfunction contribute to a broad spectrum of neurodegenerative diseases, including Alzheimer's disease (AD) and related dementias (AD/ADRD). The goal is to use in vivo animal models and human cell culture models to examine how tau regulation of mitochondrial reverse electron transfer (RET) is...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $717,709 to Weill Medical College of Cornell University to conduct research on the mechanisms underlying the propagation of tau aggregates in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research aims to discover AD-relevant cellular machinery involved in the spread of misfolded tau proteins using advanced proteomic and transcriptomic techniques. The work will be carried out...
This Project Grant award of $372,690 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to discover the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The project will develop new statistical methods to uncover how amyloid-beta, tau accumulation, and cognition are causally related in different AD subpopulations. The goal is to reveal optimal treatment windows and target groups for therapies that reduce amyloid-beta or...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at Virginia Commonwealth University (VCU) to investigate the effect of the trans-synaptic spread of pathogenic tau protein in the hippocampus and its impact on vulnerable neuron subtypes in Alzheimer's disease (AD). The $408,638 award, effective from August 1, 2024 to July 31, 2026, will involve the use of adeno-associated viral vector transfection, immunofluorescence, and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $663,376 to The Regents of the University of California, San Francisco to explore the molecular mechanisms underlying the heterogeneity of Alzheimer's disease and related dementias. The project aims to identify key genes that mediate the selective vulnerability of brain regions to distinct pathological protein conformers, such as tau and alpha-synuclein, using a novel computational modeling...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $784,596 to Northeastern University to conduct comprehensive and cell type-specific proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The project aims to substantially expand understanding of protein dysfunctions in AD by applying state-of-the-art proteomic methods paired with proteogenomics across multiple brain regions, AD stages,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...

This Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) aims to examine the influence of sociodemographic and medical factors on the performance of the plasma biomarker p-tau217 in diverse and at-risk populations for Alzheimer's disease (AD). The $369,300 award, which runs from August 2024 to April 2029, will fund research activities at Vanderbilt University Medical Center to: 1) quantify the impact of sociodemographic and medical factors on p-tau217 levels in a cohort of 3,500 individuals, 2) evaluate these factors as mediators of the association between p-tau217 and incident dementia, and 3) investigate racial differences in the relationship between p-tau217 and dementia. This work seeks to improve the understanding of how p-tau217 performance may be affected in populations disproportionately impacted by AD, with the goal of advancing the use of this biomarker for early AD detection and intervention.

Generated 8/5/25, 4:20 AM