This $626,429 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research to investigate the role of the carbohydrate responsive element binding protein (CHREBP) and its isoforms in liver metabolism and metabolic disorders. The project aims to resolve contradictory findings on CHREBP's effects and better understand its influence on conditions like metabolic-associated steatohepatitis, dyslipidemia, and cardiometabolic diseases....
This Project Grant award of $1,508,800.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research conducted by The University of Texas Southwestern Medical Center (UT Southwestern) to elucidate the role of somatic genetics in chronic liver disease pathways. The research aims to 1) identify adaptive genetic pathways specific to liver disease etiologies,...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding research to investigate intracellular cholesterol biosynthesis as a regulator of polycystic kidney disease (PKD) progression. The $504,621 award to the University of Texas Southwestern Medical Center will support a 5-year research project to: 1) determine if reducing...
This Project Grant award of $223,176 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports a training and research program led by Dr. Rebecca Davidson at the University of Michigan. The goal is to investigate the role of mitochondrial DNA damage in beta-cell dysfunction and failure in diabetes. The program will provide Dr. Davidson with hands-on training in molecular,...
This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research at the Pennington Biomedical Research Center to examine the role of the mitochondrial protein SLC25A25 in the onset and progression of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH)....
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $172,300.00 to the University of California, Los Angeles (UCLA) to investigate the role of peroxisomal PEX family proteins, specifically PEX6 and PEX14, in regulating hepatic bile acid and lipid metabolism. The research aims to determine how disrupting these PEX proteins affects the...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $243,590 to the University of Chicago to study the role of the mitophagy receptor BNIP3 in regulating lipid homeostasis in the liver. The goal is to define the mechanisms by which BNIP3 decreases lipid droplet content through promoting mitophagy and lipophagy, particularly in the...
This federal Project Grant award of $115,288, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, supports research at the University of North Carolina at Chapel Hill (UNC-CH) to investigate the transcriptional regulation of mitochondrial metabolism in human intestinal stem cells. The 5-year award, starting on May 15, 2025, will enable Principal Investigator Dr. Joseph Burclaff,...
This federal Project Grant award of $675,660.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was granted to the Beth Israel Deaconess Medical Center, Inc. (Bidmc) to conduct research focused on understanding the regulation and requirements for coenzyme A (CoA) biosynthesis, and how dysregulation of CoA synthesis is related to metabolic diseases...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $579,097 Project Grant to The University of Texas MD Anderson Cancer Center. The grant, with a period of performance from July 1, 2025 to March 31, 2030, will fund research to identify and dissect the molecular mechanisms of regulators affecting mitochondrial electron transport chain (ETC) dysfunction in diabetic...