This federal Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the carbohydrate responsive element binding protein (ChREBP) and its isoforms in liver metabolism, metabolic diseases, and associated steatohepatitis. The $626,429 award, effective from July 1, 2025 to May 31, 2030, will employ genetic interventions in mouse models and molecular phenotyping to study the metabolic pathways and physiological impacts influenced by ChREBP isoforms. The project seeks to resolve contradictory findings on the roles of ChREBP isoforms in liver function and systemic metabolism, with the goal of enhancing understanding of metabolic disease mechanisms and potentially leading to improved diagnostic and therapeutic strategies for conditions like dyslipidemia, diabetes, and metabolic-associated fatty liver disease.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $626.4k | 7/1/25 |