The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $504,621 Project Grant (R01DK139033) to The University of Texas Southwestern Medical Center to investigate the role of intracellular cholesterol biosynthesis in regulating the progression of autosomal dominant polycystic kidney disease (ADPKD). The funding, provided through NIDDK's Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support a 5-year research project to determine if reducing or enhancing intracellular cholesterol levels can either aggravate or slow cyst growth in ADPKD. The project aims to advance the understanding of ADPKD pathogenesis and identify potential new therapeutic approaches targeting the cholesterol biosynthesis pathway.
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