Project Grant K08AR086998
- Federal Grant Award Summary The University of California, San Francisco received a $1,031,877 Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), awarded July 1, 2025, with a completion date of April 30, 2030. This research initiative, titled "Endogenous Retroviruses in Autoimmunity: T Cell Repertoire, Tolerance, and Disease," will deliver biomedical...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded $1.9M in Project Grant funding (CFDA 93.846: Arthritis, Musculoskeletal and Skin Diseases Research) to the University of California, San Francisco on September 15, 2025, for a three-year research initiative through August 31, 2028. This award supports research into the dysregulation of epidermal innate immune signaling as a driver of psoriatic arthritis (PsA). The project...
- Federal Grant Award Summary The University of California, San Francisco (UCSF) received a $243,950 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 19, 2025, with a completion date of June 30, 2028. The research project deliverables include the development of machine learning-based prognostic models designed to predict which children...
- Federal Grant Award Summary This $172,560 Project Grant, awarded June 1, 2026, through May 31, 2031, by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports translational research investigating the role of SAP (SLAM-associated protein) positive T cells in lupus nephritis (LN). The research aims to elucidate the immune mechanisms driving tubulointerstitial inflammation...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $170,964 Project Grant to Yale University on May 15, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This five-year career development award supports research investigating the mechanisms by which retroelements contribute to systemic lupus erythematosus (SLE) autoimmunity. The research will generate scientific outputs...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $169,560 Project Grant to The Regents of the University of California, San Francisco (UCSF) effective July 1, 2025, through May 31, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This mentored career development award funds comprehensive research to elucidate the role of endogenous opioid peptides—specifically enkephalin and...
- Federal Project Grant Award Summary The University of California, San Francisco received a $1.36 million Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), awarded August 15, 2025, with completion anticipated May 31, 2030. This research project will develop and validate age-relative biochemical measures of intervertebral disc health using spin-lock T1ρ (T1R)...
- Federal Grant Award Summary Massachusetts General Hospital received a $165,240 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective June 1, 2026 through May 31, 2031. The award funds research to unravel shared and unique mechanisms of autoimmunity using systems immunology approaches, with a particular focus on regulatory T (Treg) cell...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Regents of the University of California, San Francisco a $219,609 Project Grant on September 5, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop an innovative in vitro methodology for detecting changes in bone matrix mechanical properties. The primary deliverable is the establishment and validation of a micropillar-based...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1.85 million Project Grant to the University of California, San Diego to conduct basic research on the role of lysine acetylation in skeletal muscle contractile function. Awarded on September 15, 2025, with completion targeted for August 31, 2028, this research project will produce scientific findings, peer-reviewed publications, and mechanistic data advancing understanding of...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant totaling $180,144 to The Regents of the University of California, San Francisco under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award, effective June 1, 2026, through April 30, 2031, supports investigator-initiated basic science research led by Dr. Taylor LaFlam examining the role of P2RY8, a G-protein-coupled receptor, in B cell tolerance and trafficking mechanisms relevant to systemic lupus erythematosus pathogenesis. The research deliverables include mechanistic characterization studies of P2RY8 function in transitional B cell negative selection, plasma cell generation and trafficking, and development of novel experimental models and functional genomics data to advance understanding of B cell biology and autoimmune disease. This project combines basic research with structured career development for an early-career pediatric rheumatologist and basic science researcher under mentorship from established immunologists and genomicists. Expected outputs include peer-reviewed scientific publications, preclinical animal model data, molecular characterization of protein variants, and foundational knowledge to inform future therapeutic development for lupus and related autoimmune conditions. The research is conducted at UCSF's San Francisco facility, leveraging the institution's established capabilities in biomedical research across immunology and translational medicine disciplines.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $180.1k | 5/29/26 |