Project Grant K08AR085766

Award Date 7/1/25
Completion Date 5/31/30
Dollars Obligated $170K
Federal Grant Program
93.846
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94143, USA
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The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $172,700 Project Grant (CFDA 93.846 Arthritis, Musculoskeletal and Skin Diseases Research) to the University of California, Irvine to develop and characterize cell-penetrating botulinum protease variants that can inhibit neurotransmitter release and immune cell signaling in skin. The goal is to create a new topical therapeutic strategy to regulate inflammation in skin diseases like psoriasis and atopic...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $196,460 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the University of Pittsburgh. The purpose of this 30-month grant, with a start date of January 30, 2025, is to develop and utilize a novel microphysiological system to study neuro-immune interactions that contribute to osteoarthritis (OA) pain. The research aims to: 1) understand how inflammatory molecules from...
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This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846), is focused on investigating the role of Staphylococcus aureus-induced itch and neuro-immune signaling in driving skin inflammation and atopic dermatitis. The $100,138 award, spanning from August 1, 2024 to July 31, 2026, will support research at Harvard Medical School to: 1) define the...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $126,174.00 to support research aimed at investigating the local immune response and granulopoiesis (production of neutrophils) in human skin during bacterial infections. The primary objectives of this 2.5-year project are to: 1) Demonstrate the role of the SDF-1/CXCR4 signaling axis in attracting and...
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This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $169,560.00 to support a 5-year research project focused on characterizing the cutaneous opioid circuitry and its role in regulating skin inflammation and sensory perception. The primary objectives are to:

  1. Identify the cellular sources of the endogenous opioid enkephalin and its function in controlling skin inflammation and sensation, particularly itch and pain.
  2. Develop advanced methods to study how the delta opioid receptor regulates the functional activity of skin-innervating sensory neurons.
  3. Assess the impact of genetically or pharmacologically modulating the enkephalin-delta opioid receptor pathway on cutaneous inflammation and itch in a murine dermatitis model.

This research, to be conducted by the University of California, San Francisco, aims to expand the understanding of endogenous opioid biology within the skin and its potential to alleviate inflammatory skin diseases characterized by chronic itch and pain.

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