Project Grant K08AI187679
- This $430,760 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), which administers the Allergy and Infectious Diseases Research program (CFDA 93.855), to the University of Pittsburgh. The grant supports research to train neutrophils, a type of white blood cell, to defend against a lethal bacterial infection of the lung caused by Pseudomonas aeruginosa. The key objectives are to establish a strategy to improve the host's immune defense against this...
- This Project Grant, valued at $868,776.00 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research to characterize a novel post-transcriptional regulator in the opportunistic pathogen Pseudomonas aeruginosa. The key objectives are to identify the direct regulatory targets of this regulator, called PhAF, under standard laboratory conditions and in clinically relevant...
- This Project Grant award of $775,184 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to elucidate the function of two small RNA genes (SicX and PA3237) that are highly expressed in human chronic Pseudomonas aeruginosa infections. The research will: (i) define the mechanism by which SicX controls its target genes; (ii) elucidate the mechanisms controlling SicX-mediated dissemination in a murine...
- This federal Project Grant award of $481,214 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to define high-risk genomic groups of the bacterium Stenotrophomonas maltophilia. The research aims to investigate how different genomic groups of S. maltophilia may impact clinical presentation and patient outcomes, as prior studies have identified certain genomic groups associated...
- This Project Grant award, valued at $160,040.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research conducted by the University of California, San Francisco (UCSF) to investigate how the bacterial pathogen Pseudomonas aeruginosa senses and responds to mechanical deformation of its cell envelope when contacting surfaces. The research aims to further...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $453,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for research on Pseudomonas aeruginosa infections and neutrophil swarming behavior. The funding will support a 2-year project to develop an ex vivo model to study how neutrophils coordinate to surround and neutralize large bacterial...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $105,076 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Trustees of Dartmouth College to study the dual function of the T6SS immunity protein TSIT in regulating Pseudomonas aeruginosa biofilm growth. The research aims to test the hypothesis that TSIT acts as a transcription factor, in addition to its role as a T6SS immunity protein, to regulate biofilm formation - a key...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $151,040 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) for the project "Investigating the Regulatory Impact of the Small Regulatory RNA BECO on Essential Virulence Factors in Pseudomonas Aeruginosa". This grant aims to investigate how the small regulatory RNA BECO regulates the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $779,915 Project Grant to the Scripps Research Institute to investigate the chromatin remodeling functions of polyphosphate condensates in the bacterial pathogen Pseudomonas aeruginosa. The grant, awarded under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), will support research to understand how polyphosphate, a polymer produced by bacteria in response to stress, interacts with the...
- This $128,655 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support Dr. Alexander Sundermann, an Assistant Professor at the University of Pittsburgh, in developing expertise in genomic epidemiology to prevent healthcare-associated infection (HAI) transmission. The funding will facilitate Dr. Sundermann's training in advanced genomic and bioinformatics techniques, biostatistical methods, and applied...
This Project Grant award of $189,146.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports a 5-year research career development program led by Dr. Glenn J. Rapsinski at the University of Pittsburgh. The project aims to study the evolution and adaptations of the pathogen Pseudomonas aeruginosa in children with tracheostomy tubes, and how these adaptations impact host responses and lead to ventilator-associated infections. The research will incorporate training in bacterial evolution and epithelial cell biology to enhance Dr. Rapsinski's expertise in host-pathogen interactions. The findings are expected to advance understanding of how P. aeruginosa colonizes artificial airways and causes device-related infections, which are a significant challenge in pediatric healthcare.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $189.1k | 8/5/25 |