Project Grant F32AI194695
- This $540,818 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research at Columbia University on the interdependency of chemical, structural, and physiological heterogeneity in Pseudomonas aeruginosa biofilms. The project aims to investigate how biofilm and infection-site conditions impact P. aeruginosa's use of lactate as a carbon source, and how the bacteria tolerate...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research on the molecular determinants and functions of bacterial polysaccharide cellular localization, with a focus on the Pseudomonas aeruginosa biofilm exopolysaccharides PSL and PEL. The $783,557 award to the University of Washington aims to examine modifications to these exopolysaccharides, explore how the SIA system controls their...
- This Project Grant, valued at $868,776.00 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research to characterize a novel post-transcriptional regulator in the opportunistic pathogen Pseudomonas aeruginosa. The key objectives are to identify the direct regulatory targets of this regulator, called PhAF, under standard laboratory conditions and in clinically relevant...
- This $422,355 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports mechanistic studies of the signaling histidine kinase GacS from the nosocomial pathogen Pseudomonas aeruginosa. The research aims to experimentally validate conformational changes in GacS predicted by molecular dynamics simulations and directly measure the impact of ligand binding on the shape and flexibility of...
- This $430,760 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), which administers the Allergy and Infectious Diseases Research program (CFDA 93.855), to the University of Pittsburgh. The grant supports research to train neutrophils, a type of white blood cell, to defend against a lethal bacterial infection of the lung caused by Pseudomonas aeruginosa. The key objectives are to establish a strategy to improve the host's immune defense against this...
- This $430,375.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research on a novel inter-membrane lipid signaling mechanism in Gram-negative bacteria like E. coli and Pseudomonas aeruginosa. The research aims to elucidate how these bacteria can sense and respond to deficiencies in their outer membrane lipopolysaccharide (LPS) content, a critical component for...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $779,915 Project Grant to the Scripps Research Institute to investigate the chromatin remodeling functions of polyphosphate condensates in the bacterial pathogen Pseudomonas aeruginosa. The grant, awarded under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), will support research to understand how polyphosphate, a polymer produced by bacteria in response to stress, interacts with the...
- This $158,000 Project Grant was awarded on June 9, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research to investigate mechanisms of nitric oxide (NO) detoxification and reactivity in the bacterial pathogen Pseudomonas aeruginosa. The research aims to understand how this opportunistic pathogen persists during immune responses involving NO production, in order...
- The federal Project Grant award of $186,354 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is being used to conduct research on the roles of protein glycosylation in prokaryotes. The project aims to perform quantitative glycoproteomic analyses of the opportunistic bacterial pathogen Pseudomonas aeruginosa during different stages of biofilm formation and in response to antibiotics. Additionally, the...
- This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to investigate the role of a Pseudomonas bacteriophage (PF phage) in promoting chronic biofilm lung infections in individuals with cystic fibrosis. The $192,672 award, effective from September 1, 2025 to August 31, 2030, will support research at Stanford University to study how the PF phage mediates...
This Project Grant award, valued at $160,040.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research conducted by the University of California, San Francisco (UCSF) to investigate how the bacterial pathogen Pseudomonas aeruginosa senses and responds to mechanical deformation of its cell envelope when contacting surfaces. The research aims to further the understanding of biofilm development by this opportunistic pathogen, which can cause life-threatening infections in vulnerable patients. The project leverages innovative microfluidic devices and single-cell fluorescence microscopy techniques to quantify the relationship between mechanical stress on the cell envelope and the activation of the Wsp signaling system, which regulates P. aeruginosa's transition to a surface-bound, biofilm lifestyle. The award period runs from December 26, 2025 to June 30, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 6/26/25 | ||
| Not listed | $80.0k | 6/26/25 | ||
| Not listed | $80.0k | 6/26/25 |