Project Grant R21AI185663
- This $430,760 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), which administers the Allergy and Infectious Diseases Research program (CFDA 93.855), to the University of Pittsburgh. The grant supports research to train neutrophils, a type of white blood cell, to defend against a lethal bacterial infection of the lung caused by Pseudomonas aeruginosa. The key objectives are to establish a strategy to improve the host's immune defense against this...
- This $2,976,652 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), aims to explore how polyamines impact methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes, two dangerous human skin pathogens. The research will investigate how these pathogens develop resistance to polyamines, which are highly toxic to them, and seek to develop novel synthetic...
- This $128,655 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support Dr. Alexander Sundermann, an Assistant Professor at the University of Pittsburgh, in developing expertise in genomic epidemiology to prevent healthcare-associated infection (HAI) transmission. The funding will facilitate Dr. Sundermann's training in advanced genomic and bioinformatics techniques, biostatistical methods, and applied...
- This Project Grant award of $189,146.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), supports a 5-year research career development program led by Dr. Glenn J. Rapsinski at the University of Pittsburgh. The project aims to study the evolution and adaptations of the pathogen Pseudomonas aeruginosa in children with tracheostomy tubes, and how these adaptations impact host responses and...
- This $420,553 federal Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to develop a single-cell technique that will measure the translation rate and transcriptome of thousands of individual bacterial cells, with a focus on understanding antibiotic tolerance in Staphylococcus aureus during chronic infections. The research will explore the heterogeneity in...
- This Project Grant, valued at $868,776.00 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research to characterize a novel post-transcriptional regulator in the opportunistic pathogen Pseudomonas aeruginosa. The key objectives are to identify the direct regulatory targets of this regulator, called PhAF, under standard laboratory conditions and in clinically relevant...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $189,558 to Duke University to identify genomic determinants of antibiotic treatment failure in Staphylococcus aureus bacteremia (SAB). The primary objectives are to: 1) Use a murine in-vivo evolution model to identify bacterial genotypes associated with SAB treatment failure, and 2) Conduct a genome-wide...
- The University of South Florida (USF) received a $470,953 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant funding supports research to determine the role and regulation of the regulatory RNA SSR42 in virulence factor regulation in Staphylococcus aureus (S. aureus). The research aims to characterize how SSR42 impacts S. aureus virulence, including effects on hemolytic...
- This Project Grant award of $115,123 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to reveal strategies for eradicating antibiotic-tolerant Staphylococcus aureus persister cells. The research aims to identify the host cells harboring intracellular S. aureus reservoirs and characterize the host and bacterial transcriptomes using single-cell approaches. Additionally, the project...
- The University of Pittsburgh received a $275,303 Project Grant award from the National Institute of General Medical Sciences (NIGMS), part of the Biomedical Research and Research Training program (CFDA 93.859), to develop predictive stochastic descriptions of microbial proliferation across the molecular, cellular, and population scales. The goal is to understand the effects of molecular and cell division noise on microbial cell size control and population dynamics, particularly in clinically...
This federal Project Grant award of $481,214 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to define high-risk genomic groups of the bacterium Stenotrophomonas maltophilia. The research aims to investigate how different genomic groups of S. maltophilia may impact clinical presentation and patient outcomes, as prior studies have identified certain genomic groups associated with higher infection rates and mortality. The 2-year project will be conducted by researchers at the University of Pittsburgh, a prominent public research university. The findings may help improve understanding of virulence factors and clinical implications for this opportunistic pathogen that is increasingly resistant to antibiotics.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $481.2k | 9/10/25 |