Project Grant K08AG086582

Award Date 9/12/24
Completion Date 6/30/29
Dollars Obligated $174K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Los Angeles, CA 90095, USA
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This Project Grant award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, provides $146,922 to the University of Southern California to conduct research aimed at triggering the selective removal of deleterious mitochondrial DNA (mtDNA) mutations from mammalian cells. The goal is to develop treatments to prevent or ameliorate age-related and pediatric diseases associated with mtDNA mutations. The research will utilize genetic and molecular biology tools, combined with...
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a comprehensive investigation into the relationship between mitochondrial function and aging-related diseases. The $2,672,656 award to The Johns Hopkins University will leverage genetic variation data, metabolomics, and proteomics to identify novel biomarkers of mitochondrial function and assess their causal associations with all-cause mortality, cardiovascular disease, and frailty. The...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $388,067 to support an interdisciplinary investigation of functional asymmetry and topological restructuring within mitochondrial networks during cellular aging. The primary awardee is Northwestern University, which will partner with the University of California, San Diego on the project. The research aims to mechanistically investigate how mitochondrial positioning and dynamics contribute to...
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