Project Grant K01AI187677
- This Project Grant award of $416,165 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate blood fitness genes in the tsetse fly symbiont Sodalis glossinidius. The central hypothesis is that S. glossinidius requires specific genes to access nutrients and survive within the blood-rich tsetse fly gut environment. The research goals are to screen S. glossinidius transposon libraries for candidate...
- This Project Grant award, valued at $736,920.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program. The funding supports research conducted by the University of California, Los Angeles (UCLA) to study the structure, assembly, and mechanisms of the trypanosome flagellum, which is essential for the transmission and infection of the Trypanosoma brucei parasite that causes African...
- The Project Grant titled "Impact of Antimalarials on Parasite Selection Through the Mosquito Vector" is funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $192,364 award, which runs from August 2025 to July 2030, supports research at Yale University to investigate the effect of antimalarial drugs taken by humans on the development of malaria parasites within mosquitoes. The...
- This $453,429 federal Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate the regulation of RNA editing in the life cycle stages of the parasitic protozoan Trypanosoma brucei. The research aims to elucidate the key proteins and mechanisms underlying differential RNA editing across the parasite's development in mammalian and insect hosts. The project, conducted by Texas A&M...
- This $570,760 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports a multidisciplinary research project to study the structure and function of intraflagellar transport (IFT) in the trypanosomatid parasite Leishmania, which causes several major human diseases. The research aims to elucidate the conserved and parasite-specific features of Leishmania...
- The University of Washington received a $458,849 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research aimed at uncovering the sensory mechanisms mosquitoes use to detect blood. The project seeks to leverage emerging single-cell RNA sequencing and high-throughput genetic analysis approaches to deeply characterize the diversity of sensory neurons in the mosquito labrum (feeding structure) and...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $707,696 to The Johns Hopkins University from November 2024 through October 2029. The funding supports research to identify volatile organic compounds in human scent signatures that modulate attractiveness to the African malaria mosquito Anopheles gambiae, a key disease vector. The research aims to characterize...
- This Project Grant award of $2,536,503 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand how the ability of Aedes aegypti mosquitoes to tolerate desiccation affects their potential as disease vectors. The research aims to identify genetic mechanisms linking desiccation tolerance to susceptibility to Zika, Chikungunya, and Dengue viruses in the mosquito midgut. Key...
- This Project Grant award of $211,038 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research at The Johns Hopkins University to investigate a new strategy for controlling mosquito populations. The key focus is on targeting the enzyme iodotyrosine deiodinase, which plays a critical role in protecting insects like fruit flies from the accumulation of harmful halotyrosines that can suppress...
- The University of California, San Francisco (UCSF) was awarded a $675,962 Project Grant by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The purpose of the grant is to characterize the interaction between human and vector behaviors in order to enhance the impact of malaria control interventions in Uganda. The project will integrate rigorous human behavioral and entomological monitoring data to elucidate...
This $131,995 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) is funding research at Yale University to investigate the response of tsetse flies to odors produced when infected with trypanosomes, the parasites that cause African sleeping sickness in humans and nagana disease in animals. The key objectives are to: Examine the electrophysiological response of tsetse fly antennal neurons to trypanosome-induced volatile compounds to identify the most effective compounds for potential use in tsetse and other insect vector control. Measure the response of tsetse odorant receptors to these trypanosome-induced odors using an in vivo expression system in Drosophila. Test behavioral responses of tsetse flies to the trypanosome-induced odors, including impacts on mating behavior. The research aims to provide new insights into parasite manipulation of insect vector behavior, which could lead to improved methods for controlling tsetse flies and the devastating diseases they transmit across Africa.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $132.0k | 8/12/25 |