Project Grant K23AI193079
- This $157,884 Project Grant, awarded on December 26, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the effects of a chromosomal inversion in the Anopheles coluzzii mosquito on gene regulation and its relationship to malaria resistance. The central hypothesis is that genetic variation between the inversion forms leads to differential enhancer activity and gene...
- This Project Grant award of $132,050 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research on the impact of the mosquito gut microbiota on regulating egg formation and malaria infection. The University of Georgia Research Foundation, Inc. is conducting this research to understand how mosquito gut microbes and insulin signaling pathways interact to influence mosquito reproduction and...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $648,924 Project Grant to Iowa State University of Science and Technology under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The project, titled "Mosquito Extracellular Vesicles in Malaria Parasite Killing and Immune Priming," aims to obtain a mechanistic understanding of the role of mosquito extracellular vesicles in the mosquito immune system's recognition and killing of...
- This Project Grant award of $699,814 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research, aims to study molecular mechanisms of Plasmodium parasite invasion in Anopheles mosquito midguts to identify novel targets for transmission-blocking malaria vaccines. The key products and services to be delivered under this award include: Functional characterization of identified mosquito and parasite proteins that mediate...
- This Cooperative Agreement award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to engineer paratransgenic bacterial strains that can interfere with the ability of mosquitoes to transmit malaria parasites. The $606,815 award, granted on April 18, 2025, will fund research to develop Asaia bogorensis bacterial strains that lack antibiotic resistance genes, are resistant to horizontal...
- This federal Project Grant award of $791,864 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify molecular factors controlling chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The research aims to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, with the goal...
- The Project Grant award R01AI187153 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on identifying genetic factors associated with sexual stage development (gametocyte formation) in the malaria parasite Plasmodium falciparum. The $700,288 award, with a project period from Nov 2024 to Oct 2029, will fund a research project at the University of South Florida to perform...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $406,450 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Harvard T.H. Chan School of Public Health. The grant supports research to develop a continuous in vitro culture system for the Plasmodium vivax malaria parasite. Key objectives include optimizing the production of host reticulocytes (young red blood cells) to support P. vivax growth, iteratively improving culture conditions...
- This Project Grant award of $211,038 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research at The Johns Hopkins University to investigate a new strategy for controlling mosquito populations. The key focus is on targeting the enzyme iodotyrosine deiodinase, which plays a critical role in protecting insects like fruit flies from the accumulation of harmful halotyrosines that can suppress...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $230,808 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University in St. Louis, Missouri. The funding will support research to identify heme-binding proteins in the malaria parasite Plasmodium falciparum and investigate their role in maintaining heme homeostasis. The project aims to better understand how the parasite detoxifies heme, an essential but redox-active...
The Project Grant titled "Impact of Antimalarials on Parasite Selection Through the Mosquito Vector" is funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $192,364 award, which runs from August 2025 to July 2030, supports research at Yale University to investigate the effect of antimalarial drugs taken by humans on the development of malaria parasites within mosquitoes. The overarching goal is to assess how increased use of long-acting antimalarials for prevention could impact parasite fitness, drug resistance, and transmission through the mosquito vector. The project combines controlled lab studies and analysis of field samples from Burkina Faso and Senegal to comprehensively analyze mosquito antimalarial uptake and its consequences for parasite evolution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/4/25 | ||
| Not listed | $192.4k | 8/4/25 |