Project Grant R01AI192971
- This Project Grant award, valued at $736,920.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program. The funding supports research conducted by the University of California, Los Angeles (UCLA) to study the structure, assembly, and mechanisms of the trypanosome flagellum, which is essential for the transmission and infection of the Trypanosoma brucei parasite that causes African...
- This $412,581 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to define the roles of specialized mitochondrial DNA polymerases (POLIB and POLID) in the replication and maintenance of the complex kinetoplast DNA network of African trypanosomes. These parasites cause neglected tropical diseases such as human African trypanosomiasis, Chagas disease,...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $239,250 Project Grant to Brown University to investigate life-cycle transitions in trypanosomatid parasites using live-cell imaging. The 2-year project, running from August 2025 to July 2027, will leverage a novel agarose microwell confinement strategy to observe cellular processes like cell division in these important human...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $133,800 to the Fundacion Instituto De Investigaciones Biotecnologicas in Argentina. The funding supports research to fully understand protein trafficking through the contractile vacuole complex (CVC) in the parasite Trypanosoma cruzi, the causative agent of Chagas disease. The research aims to...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $777,360 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Washington University to advance research on lymphatic filariasis (LF) elimination. The project aims to leverage genomic epidemiology to monitor the number of reproductively active adult parasites, differentiate new and established maternal parasite lineages, and understand the drivers of LF resurgence in areas that...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $130,000.00 to Fort Lewis College for a project titled "Using Natural Products to Decipher Essential Host-Parasite Interactions in Visceral Leishmaniasis." The goal is to identify the mechanisms of action of sulforaphane, a natural compound, to inhibit the replication of Leishmania parasites within host...
- This $453,429 federal Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate the regulation of RNA editing in the life cycle stages of the parasitic protozoan Trypanosoma brucei. The research aims to elucidate the key proteins and mechanisms underlying differential RNA editing across the parasite's development in mammalian and insect hosts. The project, conducted by Texas A&M...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant titled "Role of Tryptophan Catabolism and AHR Pathways in Natural Resistance of Leishmania (Viannia) panamensis to Antimonial Drug" to the University of Maryland, College Park on September 24, 2025. The $193,733 award supports research to investigate the resistance of the Leishmania (Viannia) panamensis parasite, a major cause of cutaneous leishmaniasis in Colombia, to antimonial drugs. The...
- This $423,500 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 22, 2025. The grant supports research to identify the molecular targets of the anti-parasitic compound Tartrolon E and determine if inhibition of the identified target proteins mediates the compound's broad anti-apicomplexan activity. The research aims to characterize the role of two rhoptry proteins,...
- This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
This $570,760 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports a multidisciplinary research project to study the structure and function of intraflagellar transport (IFT) in the trypanosomatid parasite Leishmania, which causes several major human diseases. The research aims to elucidate the conserved and parasite-specific features of Leishmania IFT, identify new adaptor proteins linking polyubiquitinated proteins to IFT trains, and determine if microtubule-associated proteins regulate IFT. The 5-year project will utilize a combination of structural biology, live-cell imaging, proteomics, and bioinformatics approaches, with the goal of identifying potential therapeutic targets for diseases affecting millions globally.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $570.8k | 8/26/25 |